Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Haojue Wang; Tao Yuan; Yi Wang; Changxing Liu; Dengju Li; Ziqing Li; Shui Sun

doi:10.1111/acel.14092

journal article Open Access Jan 29, 2024

Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Haojue Wang Tao Yuan

Yi Wang

Changxing Liu

Dengju Li Ziqing Li

Shui Sun

Aging Cell Vol. 23 No. 4 · Wiley

View at Publisher Save 10.1111/acel.14092

Abstract

AbstractOsteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the aging population, and often leads to joint pain, disability, and a diminished quality of life. Although considerable research has been conducted, the precise molecular mechanisms propelling OA pathogenesis continue to be elusive, thereby impeding the development of effective therapeutics. Notably, recent studies have revealed subchondral bone lesions precede cartilage degeneration in the early stage of OA. This development is marked by escalated osteoclast‐mediated bone resorption, subsequent imbalances in bone metabolism, accelerated bone turnover, and a decrease in bone volume, thereby contributing significantly to the pathological changes. While the role of aging hallmarks in OA has been extensively elucidated from the perspective of chondrocytes, their connection with osteoclasts is not yet fully understood. There is compelling evidence to suggest that age‐related abnormalities such as epigenetic alterations, proteostasis network disruption, cellular senescence, and mitochondrial dysfunction, can stimulate osteoclast activity. This review intends to systematically discuss how aging hallmarks contribute to OA pathogenesis, placing particular emphasis on the age‐induced shifts in osteoclast activity. It also aims to stimulate future studies probing into the pathological mechanisms and therapeutic approaches targeting osteoclasts in OA during aging.

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Details

Published: Jan 29, 2024
Vol/Issue: 23(4)
License: View

Authors

H

Haojue Wang

Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong China

T

Tao Yuan

Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong China

Y

Yi Wang

Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China; Orthopaedic Research Laboratory, Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China

C

Changxing Liu

Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong China

D

Dengju Li

Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China; Orthopaedic Research Laboratory, Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China

Z

Ziqing Li

Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China; Orthopaedic Research Laboratory, Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China

S

Shui Sun

Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong China; Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China; Orthopaedic Research Laboratory, Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China

Funding

National Natural Science Foundation of China Award: 82100936

Taishan Scholar Foundation of Shandong Province Award: tsqnz20221170

Natural Science Foundation of Shandong Province Award: ZR2021QH077

Cite This Article

Haojue Wang, Tao Yuan, Yi Wang, et al. (2024). Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging. Aging Cell, 23(4). https://doi.org/10.1111/acel.14092

Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

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