Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

Ferenc Torma; Csaba Kerepesi; Mátyás Jókai; Gergely Babszki; Erika Koltai; Balázs Ligeti; Regina Kalcsevszki; Kristen M. McGreevy; Steve Horvath; Zsolt Radak

doi:10.1111/acel.14101

journal article Open Access Feb 27, 2024

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

Ferenc Torma Csaba Kerepesi

Mátyás Jókai Gergely Babszki Erika Koltai Balázs Ligeti

Regina Kalcsevszki Kristen M. McGreevy Steve Horvath

Zsolt Radak

Aging Cell Vol. 23 No. 4 · Wiley

View at Publisher Save 10.1111/acel.14101

Abstract

Abstract
Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.

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References

Details

Published: Feb 27, 2024
Vol/Issue: 23(4)
License: View

Authors

F

Ferenc Torma

Research Institute of Sport Science Hungarian University of Sport Science Budapest Hungary; Sports Neuroscience Division, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences University of Tsukuba Tsukuba Ibaraki Japan; Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sport Sciences University of Tsukuba Tsukuba Ibaraki Japan

C

Csaba Kerepesi

Institute for Computer Science and Control (SZTAKI) Hungarian Research Network (HUN‐REN) Budapest Hungary

M

Mátyás Jókai

Research Institute of Sport Science Hungarian University of Sport Science Budapest Hungary

G

Gergely Babszki

Research Institute of Sport Science Hungarian University of Sport Science Budapest Hungary

E

Erika Koltai

Research Institute of Sport Science Hungarian University of Sport Science Budapest Hungary

B

Balázs Ligeti

Faculty of Information Technology and Bionics Pázmány Péter Catholic University Budapest Hungary

R

Regina Kalcsevszki

Faculty of Information Technology and Bionics Pázmány Péter Catholic University Budapest Hungary

K

Kristen M. McGreevy

Department of Biostatistics, Fielding School of Public Health University of California Los Angeles Los Angeles California USA

S

Steve Horvath

Department of Biostatistics, Fielding School of Public Health University of California Los Angeles Los Angeles California USA; Altos Labs, Cambridge Institute of Science Cambridge UK

Z

Zsolt Radak

Research Institute of Sport Science Hungarian University of Sport Science Budapest Hungary; Waseda University Tokorozawa Japan

Funding

European Commission Award: RRF‐2.3.1‐21‐2022‐00004

Cite This Article

Ferenc Torma, Csaba Kerepesi, Mátyás Jókai, et al. (2024). Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness. Aging Cell, 23(4). https://doi.org/10.1111/acel.14101

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

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