InternationalConsensus on drug allergy

P. Demoly; N. F. Adkinson; K. Brockow; M. Castells; A. M. Chiriac; P. A. Greenberger; D. A. Khan; D. M. Lang; H.‐S. Park; W. Pichler; M. Sánchez‐Borges; T. Shiohara; B. Y.‐H. Thong

doi:10.1111/all.12350

journal article Feb 21, 2014

InternationalConsensus on drug allergy

P. Demoly N. F. Adkinson K. Brockow M. Castells A. M. Chiriac P. A. Greenberger D. A. Khan D. M. Lang H.‐S. Park W. Pichler M. Sánchez‐Borges T. Shiohara B. Y.‐H. Thong

Allergy Vol. 69 No. 4 pp. 420-437 · Wiley

View at Publisher Save 10.1111/all.12350

Abstract

AbstractWhen drug reactions resembling allergy occur, they are called drug hypersensitivity reactions (DHRs) before showing the evidence of either drug‐specific antibodies or T cells.DHRs may be allergic or nonallergic in nature, with drug allergies being immunologically mediatedDHRs. These reactions are typically unpredictable. They can be life‐threatening, may require or prolong hospitalization, and may necessitate changes in subsequent therapy. Both underdiagnosis (due to under‐reporting) and overdiagnosis (due to an overuse of the term ‘allergy’) are common. A definitive diagnosis of such reactions is required in order to institute adequate treatment options and proper preventive measures. Misclassification based solely on theDHRhistory without further testing may affect treatment options, result in adverse consequences, and lead to the use of more‐expensive or less‐effective drugs, in contrast to patients who had undergone a complete drug allergy workup. Several guidelines and/or consensus documents on general or specific drug class‐inducedDHRs are available to support the medical decision process. The use of standardized systematic approaches for the diagnosis and management ofDHRs carries the potential to improve outcomes and should thus be disseminated and implemented. Consequently, theInternationalCollaboration inAsthma,Allergy andImmunology (iCAALL), formed by theEuropeanAcademy ofAllergy andClinicalImmunology (EAACI), theAmericanAcademy ofAllergy,Asthma andImmunology (AAAAI), theAmericanCollege ofAllergy,Asthma andImmunology (ACAAI), and theWorldAllergyOrganization (WAO), has decided to issue anInternationalCONsensus (ICON) on drug allergy. The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences and deficiencies of evidence, thus providing a comprehensive reference document for the diagnosis and management of DHRs.

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817

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References

Details

Published: Feb 21, 2014
Vol/Issue: 69(4)
Pages: 420-437
License: View

Authors

P

P. Demoly

Département de Pneumologie et Addictologie Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, France and Sorbonne Universités Paris France

N

N. F. Adkinson

Division of Allergy and Clinical Immunology The Johns Hopkins Asthma and Allergy Center The Hopkins Bayview Medical Campus Baltimore MD USA

K

K. Brockow

Department of Dermatology and Allergology Biederstein Technische Universität München Munich Germany

M

M. Castells

Division of Rheumatology, Allergy and Immunology Department of Medicine Brigham and Women's Hospital Boston MA

A

A. M. Chiriac

Département de Pneumologie et Addictologie Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, France and Sorbonne Universités Paris France

P

P. A. Greenberger

Division of Allergy‐Immunology Northwestern University Feinberg School of Medicine Chicago IL

D

D. A. Khan

Division of Allergy & Immunology University of Texas Southwestern Medical Center Dallas TX

D

D. M. Lang

Department of Allergy/Immunology Respiratory Institute Cleveland Clinic Foundation Cleveland OH USA

H

H.‐S. Park

Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea

W

W. Pichler

Division of Allergology Department of Rheumatology and Allergology/Clinical Immunology Inselspital, University of Bern Bern Switzerland

M

M. Sánchez‐Borges

Allergy and Clinical Immunology Department Centro Medico Docente La Trinidad Caracas Venezuela

T

T. Shiohara

Department of Dermatology Kyorin University School of Medicine Tokyo Japan

B

B. Y.‐H. Thong

Department of Rheumatology, Allergy and Immunology Tan Tock Seng Hospital Singapore

Cite This Article

P. Demoly, N. F. Adkinson, K. Brockow, et al. (2014). InternationalConsensus on drug allergy. Allergy, 69(4), 420-437. https://doi.org/10.1111/all.12350

InternationalConsensus on drug allergy

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