Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate

F. C. Gomes; L. G. A. Chuffa; W. R. Scarano; P. F. F. Pinheiro; W. J. Fávaro; R. F. Domeniconi

doi:10.1111/andr.12162

journal article Mar 24, 2016

Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate

F. C. Gomes L. G. A. Chuffa W. R. Scarano P. F. F. Pinheiro W. J. Fávaro R. F. Domeniconi

Andrology Vol. 4 No. 3 pp. 473-480 · Wiley

View at Publisher Save 10.1111/andr.12162

Abstract

SummaryAge is a key factor in the development of prostatic lesions. An increase in reactive oxygen species levels occurs during aging. Furthermore, the indiscriminate use of anabolic androgenic steroids and physical exercise alter the availability of hormones and may promote the appearance of lesions. This study examined whether the use of nandrolone decanoate (ND), associated or not with resistance exercise training, affects the pathways related to the inflammatory response in the ventral prostate of adult and aged rats. Sprague‐Dawley rats were distributed into eight experimental groups: sedentary with ND, sedentary without ND, exercise with ND, and exercise without ND. The animals performed resistance exercise training and received ND two times/week (5 mg/kg, i.m.) for 8 weeks. Adult rats were killed immediately following treatment completion, and aged rats remained untreated until reaching 300 days of age. The adult animals that received ND and performed resistance exercise training showed a higher occurrence of lesions with TLR4 activation. Marked IL‐6 expression occurred in the group that performed resistance exercise training. The group exposed to ND showed overexpression of TLR2, TLR4, NOX1, Nrf2, TNF‐α, and P38MAPK. The animals that received ND and performed training showed increase levels of NFκB, IRF3, IL‐6, TNF‐α, and NOX1. TLR2 and TLR4 showed no upregulation in the aged animals. The groups exercise + ND showed lesions in the adult stage and after aging, followed by molecular alterations. We concluded that nandrolone decanoate and resistance exercise training can promote the onset of prostatic tumors in the adult stage, and during aging, activating pathways involved in the inflammatory response.

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References

52

[1]

10.1080/09674845.2013.11669935

[2]

Akira S "Toll‐like receptor signaling" Immunology (2004)

[3]

10.1007/s10875-009-9297-5

[4]

10.1152/physrev.00044.2005

[5]

10.1016/j.biochi.2007.01.012

[6]

10.1055/s-2007-965808

[7]

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Marion M. Bradford

Analytical Biochemistry 10.1016/0003-2697(76)90527-3

[8]

Brogårdh C "Effects of cardiorespiratory fitness and muscle‐resistance training after stroke" Exerc Sports Health Promot Dis Disabil (2012)

[9]

10.1111/j.1365-2265.2006.02715.x

[10]

10.1006/hbeh.1997.1355

[11]

10.1016/j.lfs.2014.11.006

[12]

10.1007/s00345-003-0365-9

[13]

10.1016/j.jsbmb.2009.10.015

[14]

10.1189/jlb.1209775

[15]

10.2165/00007256-200636040-00004

[16]

10.1016/j.steroids.2012.12.009

[17]

10.1016/j.ejca.2010.07.028

[18]

González‐Reyes S "Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis" BMC Cancer (2011)

[19]

10.1007/s11892-013-0372-1

[20]

10.2174/1381612013398103

[21]

10.1007/s00441-010-1047-8

[22]

10.1101/gad.17224711

[23]

10.1016/j.smim.2006.12.004

[24]

10.1016/j.canlet.2008.12.011

[25]

10.1016/j.mrfmmm.2009.09.007

[26]

10.1177/1947601913507951

[27]

10.1016/j.eururo.2006.12.011

[28]

10.7314/apjcp.2013.14.7.3993

[29]

10.1002/biof.5520290103

[30]

10.1002/jcp.24314

[31]

Liu TC "Exercise and testosterone" Adapt Med (2009)

[32]

Longbiao Z "Association of TLR2 and TLR4 polymorphisms with risk of cancer: a meta‐analysis" PLoS ONE (2013)

[33]

10.1007/s00134-010-1983-5

[34]

10.1152/ajpheart.00328.2013

[35]

10.1089/ars.2006.8.1775

[36]

10.1016/s0167-5273(02)00247-4

[37]

10.1152/japplphysiol.01064.2003

[38]

10.1038/ni.1727

[39]

Exercise and the Immune System: Regulation, Integration, and Adaptation

Bente Klarlund Pedersen, Laurie Hoffman-Goetz

Physiological Reviews 10.1152/physrev.2000.80.3.1055

[40]

10.1016/j.resp.2010.09.016

[41]

10.1176/ajp.145.4.487

[42]

Pradere JP "The Yin and Yang of toll‐like receptors in cancer" Oncogene (2013)

[43]

10.1095/biolreprod.106.053967

[44]

10.1016/j.freeradbiomed.2013.02.009

[45]

10.1097/01.ju.0000082712.41945.17

[46]

10.1016/j.bbamcr.2011.01.034

[47]

10.1158/0008-5472.can-03-0946

[48]

10.1111/j.1742-7843.2009.00495.x

[49]

10.1007/s12026-012-8293-7

[50]

10.1038/nrurol.2014.22

Showing 50 of 52 references

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Details

Published: Mar 24, 2016
Vol/Issue: 4(3)
Pages: 473-480
License: View

Authors

F

F. C. Gomes

Department of Anatomy Institute of Biosciences Univ Estadual Paulista (UNESP) Botucatu SP Brazil

L

L. G. A. Chuffa

Department of Anatomy Institute of Biosciences Univ Estadual Paulista (UNESP) Botucatu SP Brazil

W

W. R. Scarano

Department of Morphology Institute of Biosciences Univ Estadual Paulista (UNESP) Botucatu SP Brazil

P

P. F. F. Pinheiro

Department of Anatomy Institute of Biosciences Univ Estadual Paulista (UNESP) Botucatu SP Brazil

W

W. J. Fávaro

Department of Morphology Institute of Biosciences Univ Estadual Paulista (UNESP) Botucatu SP Brazil; Department of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP) Campinas SP Brazil

R

R. F. Domeniconi

Department of Anatomy Institute of Biosciences Univ Estadual Paulista (UNESP) Botucatu SP Brazil

Funding

State of São Paulo Research Foundation (FAPESP) Award: 2013/00649-7

Cite This Article

F. C. Gomes, L. G. A. Chuffa, W. R. Scarano, et al. (2016). Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate. Andrology, 4(3), 473-480. https://doi.org/10.1111/andr.12162

Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate

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