Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options

Tom Tanbo; Peter Fedorcsak

doi:10.1111/aogs.13082

journal article Jan 30, 2017

Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options

Tom Tanbo Peter Fedorcsak

Acta Obstetricia et Gynecologica Scandinavica Vol. 96 No. 6 pp. 659-667 · Wiley

View at Publisher Save 10.1111/aogs.13082

Abstract

AbstractEndometriosis is a common condition in women of reproductive age. In addition to pain, endometriosis may also reduce fertility. The causes of infertility in women with endometriosis may range from anatomical distortions due to adhesions and fibrosis to endocrine abnormalities and immunological disturbances. In some cases, the various pathophysiological disturbances seem to interact through mechanisms so far not fully understood. Whether surgery should be offered as a treatment option in endometriosis‐associated infertility has become controversial, partly due to its modest or undocumented effect. Medical or hormonal treatment alone has little or no effect and should only be used in conjunction with assisted reproductive technology (ART). Of the various methods of ART, intrauterine insemination, due to its simplicity, can be recommended in women with minimal or mild peritoneal endometriosis, even though insemination may yield a lower success rate than in women without endometriosis. In vitro fertilization (IVF) is an effective treatment option in less‐advanced disease stages, and the success rates are similar to the results in other causes of infertility. However, women with more advanced stages of endometriosis have lower success rates with IVF.

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Details

Published: Jan 30, 2017
Vol/Issue: 96(6)
Pages: 659-667
License: View

Authors

T

Tom Tanbo

Department of Reproductive Medicine Oslo University Hospital Oslo Norway; Institute of Clinical Medicine University of Oslo Oslo Norway

P

Peter Fedorcsak

Department of Reproductive Medicine Oslo University Hospital Oslo Norway; Institute of Clinical Medicine University of Oslo Oslo Norway

Cite This Article

Tom Tanbo, Peter Fedorcsak (2017). Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstetricia et Gynecologica Scandinavica, 96(6), 659-667. https://doi.org/10.1111/aogs.13082

Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options

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