Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation

B. H. Mullish; M. S. Kabir; M. R. Thursz; A. Dhar

doi:10.1111/apt.12925

journal article Sep 01, 2014

Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation

B. H. Mullish M. S. Kabir M. R. Thursz A. Dhar

Alimentary Pharmacology & Therapeutics Vol. 40 No. 8 pp. 880-892 · Wiley

View at Publisher Save 10.1111/apt.12925

Abstract

SummaryBackgroundThe scale of depression in patients with chronic liver disease (CLD) and those who have received orthotopic liver transplantation (OLT) is poorly characterised. Clinicians are uncertain of how best to manage depression within these patients.AimsTo review the literature evaluating both the prevalence and impact of depression in patients with CLD and post‐OLT, and to assess the safety and efficacy of antidepressant use within this context.MethodsA PubMed search using the phrases ‘chronic liver disease’, ‘cirrhosis’, ‘liver transplantation’, ‘depression’, ‘antidepressant’ and the names of specific causes of liver disease and individual antidepressants.ResultsOver 30% of cirrhotic patients have depressive features, and they experience worse clinical outcomes than nondepressed cirrhotic patients. CLD patients with chronic hepatitis C are particularly prone to depression, partly related to the use of interferon therapy. OLT patients with depression have higher mortality rates than nondepressed patients; appropriate antidepressant use reverses this effect. Selective serotonin reuptake inhibitors (SSRIs) and selective noradrenaline reuptake inhibitors (SNRIs) are effective and generally safe in both CLD and OLT patients.ConclusionsDepression is much more prevalent in CLD or OLT patients than is generally recognised, and it adversely affects clinical outcomes. The reasons for this relationship are complex and multifactorial. Antidepressants are effective in both CLD and post‐OLT, although lower doses or a reduced dosing frequency may be required to minimise side effects, e.g. exacerbation of hepatic encephalopathy. Further research is needed to establish optimal management of depression in these patients, including the potential role of nonpharmacological treatments.

Topics

No keywords indexed for this article. Browse by subject →

References

107

[1]

10.1016/s0140-6736(12)61729-2

[2]

10.1159/000107563

[3]

10.1159/000323404

[4]

10.1016/j.ijcard.2012.03.143

[5]

On the Validity of the Beck Depression Inventory

Paul Richter, Joachim Werner, Andrés Heerlein et al.

Psychopathology 10.1159/000066239

[6]

10.1016/s1542-3565(03)00315-x

[7]

10.1016/j.dld.2005.01.020

[8]

10.1007/s11011-012-9364-0

[9]

10.1023/a:1018898106656

[10]

10.1002/lt.22231

[11]

10.1097/tp.0b013e3181a440ae

[12]

10.1186/1471-244x-11-182

[13]

10.1007/s11011-005-2472-3

[14]

10.1007/bf02985102

[15]

10.1503/jpn.090076

[16]

10.1016/s0168-8278(01)00026-5

[17]

10.1016/j.ijcard.2013.05.068

[18]

10.1001/archinte.160.14.2101

[19]

10.1176/ajp.144.4.437

[20]

Koff WC "Catecholamine‐induced suppression of interleukin‐1 production" Lymphokine Res (1986)

[21]

10.1016/s0140-6736(00)05270-3

[22]

10.1053/jhep.2002.30688

[23]

10.1186/1745-0179-3-22

[24]

10.1053/gast.2002.34750

[25]

10.1016/s0022-3999(00)00155-0

[26]

10.1016/j.genhosppsych.2005.06.006

[27]

10.1016/j.jhep.2012.07.037

[28]

10.1016/j.psym.2012.09.005

[29]

10.1097/00042737-200512000-00019

[30]

10.1111/j.1365-2893.2007.00885.x

[31]

10.1111/j.1365-2893.2011.01510.x

[32]

10.1056/nejm200103293441303

[33]

10.2165/00023210-200519020-00002

[34]

10.1053/jhep.2003.50031

[35]

10.1038/sj.mp.4001119

[36]

10.1002/hep.23699

[37]

10.1097/jcp.0b013e31825d9982

[38]

10.1002/hep.23743

[39]

10.1016/j.psym.2010.12.019

[40]

10.1002/hep.510270132

[41]

10.1111/j.1478-3231.2008.01696.x

[42]

10.2146/ajhp060647

[43]

10.1136/bmj.287.6403.1417

[44]

10.1093/alcalc/agh257

[45]

10.1097/tp.0b013e3181872710

[46]

10.1097/01.psy.0000221276.17823.df

[47]

10.1111/liv.12165

[48]

10.1016/j.jhep.2013.10.035

[49]

10.1016/j.jhep.2007.01.036

[50]

10.1111/j.1600-6143.2011.03496.x

Showing 50 of 107 references

Cited By

131

Exploring the Humanistic Care Competencies of Nurses in Infectious Disease Hospitals in China: A Modified Delphi Study

Qiuyun Li, Xingmiao Feng · 2025

Journal of Advanced Nursing

The association between mental illness and all-cause mortality in patients with cirrhosis: a Veterans Affairs retrospective cohort study

Lauren R. Shaffer, David E. Kaplan · 2023

Hepatology Communications

Management of Psychiatric Disorders in Patients with Hepatic and Gastrointestinal Diseases

Vikas Menon, Ramdas Ransing · 2022

Indian Journal of Psychiatry

Hepatic encephalopathy and depression in chronic liver disease: is the common link systemic inflammation?

Victoria Tatiana Kronsten, Debbie Lindsay Shawcross · 2022

Analytical Biochemistry

Correlation between anxiety-depression symptoms and immune characteristics in inpatients with 2019 novel coronavirus in Wuhan, China

Congchong Wu, Zhiying Zhou · 2021

Journal of Psychiatric Research

Metrics

131

Citations

107

References

Details

Published: Sep 01, 2014
Vol/Issue: 40(8)
Pages: 880-892
License: View

Authors

B

B. H. Mullish

Section of Hepatology Faculty of Medicine Imperial College London St Mary's Hospital Campus Paddington London UK

M

M. S. Kabir

Section of Hepatology Faculty of Medicine Imperial College London St Mary's Hospital Campus Paddington London UK

M

M. R. Thursz

Section of Hepatology Faculty of Medicine Imperial College London St Mary's Hospital Campus Paddington London UK

A

A. Dhar

Section of Hepatology Faculty of Medicine Imperial College London St Mary's Hospital Campus Paddington London UK

Cite This Article

B. H. Mullish, M. S. Kabir, M. R. Thursz, et al. (2014). Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation. Alimentary Pharmacology & Therapeutics, 40(8), 880-892. https://doi.org/10.1111/apt.12925

Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation

You May Also Like