A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Jiangling Peng; Mingjie Fan; Chelsea An; Feng Ni; Wendong Huang; Jiankang Luo

doi:10.1111/bcpt.13710

journal article Feb 06, 2022

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Jiangling Peng

Mingjie Fan Chelsea An Feng Ni Wendong Huang

Jiankang Luo

Basic & Clinical Pharmacology & Toxicology Vol. 130 No. 4 pp. 439-456 · Wiley

View at Publisher Save 10.1111/bcpt.13710

Abstract

AbstractCannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis extracts which has high affinity on a series of receptors, including Type 1 cannabinoid receptor (CB1), Type 2 cannabinoid receptor (CB2), GPR55, transient receptor potential vanilloid (TRPV) and peroxisome proliferator‐activated receptor gamma (PPARγ). By modulating the activities of these receptors, CBD exhibits multiple therapeutic effects, including neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti‐inflammatory, analgesic and anticancer properties. CBD could also be applied to treat or prevent COVID‐19 and its complications. Here, we provide a narrative review of CBD's applications in human diseases: from mechanism of action to clinical trials.

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Metrics

246

Citations

168

References

Details

Published: Feb 06, 2022
Vol/Issue: 130(4)
Pages: 439-456
License: View

Authors

J

Jiangling Peng

Department of Diabetes Complications and Metabolism, Beckman Research Institute City of Hope National Medical Center Duarte California USA

M

Mingjie Fan

Department of Diabetes Complications and Metabolism, Beckman Research Institute City of Hope National Medical Center Duarte California USA

C

Chelsea An

Department of Diabetes Complications and Metabolism, Beckman Research Institute City of Hope National Medical Center Duarte California USA

F

Feng Ni

Institute of Drug Discovery Technology Ningbo University Ningbo China

W

Wendong Huang

Department of Diabetes Complications and Metabolism, Beckman Research Institute City of Hope National Medical Center Duarte California USA

J

Jiankang Luo

Chemtech Zone Inc Alhambra California USA

Cite This Article

Jiangling Peng, Mingjie Fan, Chelsea An, et al. (2022). A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD). Basic & Clinical Pharmacology & Toxicology, 130(4), 439-456. https://doi.org/10.1111/bcpt.13710

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

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