Bipolar disorder: Trimodal age‐at‐onset distribution

Sorcha Bolton; Jeremy Warner; Eli Harriss; John Geddes; Kate E. A. Saunders

doi:10.1111/bdi.13016

journal article Open Access Nov 03, 2020

Bipolar disorder: Trimodal age‐at‐onset distribution

Sorcha Bolton

Jeremy Warner

Eli Harriss

John Geddes Kate E. A. Saunders

Bipolar Disorders Vol. 23 No. 4 pp. 341-356 · Wiley

View at Publisher Save 10.1111/bdi.13016

Abstract

AbstractObjectiveBipolar disorder (BD) is a chronic mental health disorder with significant morbidity and mortality. Age at onset (AAO) may be a key variable in delineating more homogeneous subgroups of BD patients. However, no known research has systematically assessed how BD age‐at‐onset subgroups should be defined.MethodsWe systematically searched the following databases: Cochrane Central Register of Controlled Trials, PsycINFO, MEDLINE, Embase, CINAHL, Scopus, Proquest Dissertations and Theses, Google Scholar and BIOSIS Previews. Original quantitative English language studies investigating AAO in BD were sought.ResultsA total of 9454 unique publications were identified. Twenty‐one of these were included in data analysis (n = 22981 BD participants). Fourteen of these studies (67%, n = 13626 participants) found a trimodal AAO distribution: early‐onset (µ = 17.3, σ = 1.19, 45% of sample), mid‐onset (µ = 26.0, = 1.72, 35%), and late‐onset (µ = 41.9, = 6.16, 20%). Five studies (24%, n = 1422 participants) described a bimodal AAO distribution: early‐onset (µ = 24.3, σ = 6.57, 66% of sample) and late‐onset (µ = 46.3, σ = 14.15, 34%). Two studies investigated cohort effects on BD AAO and found that when the sample was not split by cohort, a trimodal AAO was the winning model, but when separated by cohort a bimodal distribution fit the data better.ConclusionsWe propose that the field conceptualises bipolar disorder age‐at‐onset subgroups as referring broadly to life stages. Demarcating BD AAO groups can inform treatment and provide a framework for future research to continue to investigate potential mechanisms of disease onset.

Topics

No keywords indexed for this article. Browse by subject →

References

86

[1]

10.1001/archgenpsychiatry.2011.12

[2]

10.1016/s2215-0366(15)00544-1

[3]

10.1111/bdi.12419

[4]

10.1111/j.1399-5618.2005.00181.x

[5]

10.1001/archpsyc.58.5.510

[6]

10.1016/j.jphysparis.2013.03.006

[7]

10.1176/appi.ajp.160.5.999

[8]

10.1016/j.jad.2008.10.021

[9]

10.1016/j.jpsychires.2010.04.009

[10]

10.1016/j.jad.2012.08.031

[11]

Adult mental health disorders and their age at onset

P. B. Jones

British Journal of Psychiatry 10.1192/bjp.bp.112.119164

[12]

Evidence Partners (2014)

[13]

Methods to systematically review and meta-analyse observational studies: a systematic scoping review of recommendations

Monika Mueller, Maddalena D’Addario, Matthias Egger et al.

BMC Medical Research Methodology 10.1186/s12874-018-0495-9

[14]

10.1017/s1092852912000296

[15]

10.1016/j.jad.2016.04.006

[16]

WickhamH.ggplot2: Elegant Graphics for Data Analysis.2016. 10.1007/978-3-319-24277-4_9

[17]

RStudio Team.RStudio: Integrated Development Environment for R.2018.

[18]

BoltonS.Open Dataset: Bipolar disorder age at onset distribution.2020.https://doi.org/10.17605/OSF.IO/XFJPR

[19]

10.1038/sj.mp.4002018

[20]

10.1016/j.jpsychires.2016.02.009

[21]

10.1016/j.euroneuro.2010.04.001

[22]

10.1017/s0033291704003307

[23]

10.1186/s40345-017-0097-1

[24]

10.1016/j.eurpsy.2014.10.005

[25]

10.1016/j.jad.2013.05.026

[26]

10.3109/15622975.2011.639801

[27]

10.1111/j.1601-5215.2009.00399.x

[28]

González Pinto A "Age at onset in bipolar I disorder: two may be better than three subgroups" J Psychiatry Ment Heal (2009)

[29]

10.1016/j.jad.2014.06.054

[30]

10.1016/j.psychres.2009.11.025

[31]

10.1111/acps.12478

[32]

10.1016/j.psychres.2010.10.033

[33]

10.1176/appi.ajp.163.2.240

[34]

10.1111/j.1399-5618.2007.00572.x

[35]

10.1111/j.1399-5618.2009.00667.x

[36]

10.1002/gps.1607

[37]

10.1016/s0165-0327(99)00111-1

[38]

10.1016/j.jaac.2014.02.008

[39]

10.1007/s00787-007-0649-5

[40]

10.1016/j.neubiorev.2017.01.022

[41]

10.1177/070674370705200702

[42]

10.1016/j.jad.2016.04.009

[43]

10.1016/j.jad.2019.07.062

[44]

10.1089/104454603322724832

[45]

10.1111/j.1399-5618.2007.00563.x

[46]

10.2174/1570159x14666160607100403

[47]

10.4088/jcp.18r12180

[48]

10.1186/s40345-017-0106-4

[49]

10.1111/camh.12231

[50]

10.1111/j.1469-7610.2009.02129.x

Showing 50 of 86 references

Metrics

89

Citations

86

References

Details

Published: Nov 03, 2020
Vol/Issue: 23(4)
Pages: 341-356
License: View

Authors

S

Sorcha Bolton

Department of Psychiatry University of Oxford Warneford Hospital Oxford UK

J

Jeremy Warner

University of Oxford Medical School John Radcliffe Hospital Oxford UK

E

Eli Harriss

Bodleian Health Care Libraries University of Oxford Oxford UK

J

John Geddes

Department of Psychiatry University of Oxford Warneford Hospital Oxford UK; Oxford Health NHS Foundation Trust Warneford Hospital Oxford UK

K

Kate E. A. Saunders

Department of Psychiatry University of Oxford Warneford Hospital Oxford UK; Oxford Health NHS Foundation Trust Warneford Hospital Oxford UK

Funding

Medical Research Council Award: MR/N013468/1

Cite This Article

Sorcha Bolton, Jeremy Warner, Eli Harriss, et al. (2020). Bipolar disorder: Trimodal age‐at‐onset distribution. Bipolar Disorders, 23(4), 341-356. https://doi.org/10.1111/bdi.13016

Bipolar disorder: Trimodal age‐at‐onset distribution

You May Also Like