Cognitive impairment in hodgkin lymphoma survivors

Estherina Trachtenberg; Tatiana Mashiach; Rachel Ben Hayun; Tamar Tadmor; Tali Fisher; Judith Aharon‐Peretz; Eldad J. Dann

doi:10.1111/bjh.15448

journal article Jul 05, 2018

Cognitive impairment in hodgkin lymphoma survivors

Estherina Trachtenberg Tatiana Mashiach Rachel Ben Hayun Tamar Tadmor Tali Fisher Judith Aharon‐Peretz Eldad J. Dann

British Journal of Haematology Vol. 182 No. 5 pp. 670-678 · Wiley

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Abstract

SummaryCancer‐related cognitive impairment (CRCI) is commonly reported post‐chemotherapy in adults with solid tumours. Hodgkin lymphoma (HL) mostly affects young adults. Data regarding CRCI in HL survivors (HLS) are scarce. The current study aimed to objectively assess CRCI incidence and characteristics in HLS. HLS, who completed first‐line (chemotherapy ± radiation) therapy and remained in complete remission for 6 months to 5 years from therapy end, were evaluated. Age‐ and education‐matched healthy individuals served as controls (n = 14). Test results were compared to population norms and healthy controls. Study participants completed self‐reported questionnaires evaluating fatigue, depression, anxiety, quality of life and cognitive function. Subjects underwent neurocognitive evaluation, assessing processing speed, memory, attention, executive functions and intelligence domains. The present study included 51 HLS with a median age of 28 years, mean education of 14·5 ± 2·5 years. Complaints related to cognitive deterioration and fatigue were significantly more severe and frequent in HLS compared to healthy controls. Objective neurocognitive evaluation demonstrated that 30% of HLS were impaired in ≥2 cognitive domains. In conclusion, the present study demonstrates that fatigue and cognitive impairment, predominantly in executive functions and memory, constitute frequent and alarming findings in HLS. These adverse effects can persist and exert an impact on all aspects of life.

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References

Details

Published: Jul 05, 2018
Vol/Issue: 182(5)
Pages: 670-678
License: View

Authors

E

Estherina Trachtenberg

Bruce Rappaport Faculty of Medicine Technion Haifa Israel

T

Tatiana Mashiach

Quality Assurance Unit Rambam Health Care Campus Haifa Israel

R

Rachel Ben Hayun

Department of Cognitive Neurology Rambam Health Care Campus Haifa Israel

T

Tamar Tadmor

Bruce Rappaport Faculty of Medicine Technion Haifa Israel; Haematology Unit Bnai Zion Medical Centre Haifa Israel

T

Tali Fisher

Department of Cognitive Neurology Rambam Health Care Campus Haifa Israel

J

Judith Aharon‐Peretz

Bruce Rappaport Faculty of Medicine Technion Haifa Israel; Department of Cognitive Neurology Rambam Health Care Campus Haifa Israel

E

Eldad J. Dann

Bruce Rappaport Faculty of Medicine Technion Haifa Israel; Department of Haematology and Bone Marrow Transplantation Rambam Health Care Campus Haifa Israel

Funding

Takeda Pharmaceutical Company

Cite This Article

Estherina Trachtenberg, Tatiana Mashiach, Rachel Ben Hayun, et al. (2018). Cognitive impairment in hodgkin lymphoma survivors. British Journal of Haematology, 182(5), 670-678. https://doi.org/10.1111/bjh.15448

Cognitive impairment in hodgkin lymphoma survivors

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