Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea

Jörg Steinmann; J Buer; T Pietschmann; E Steinmann

doi:10.1111/bph.12009

journal article Feb 20, 2013

Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea

Jörg Steinmann J Buer T Pietschmann E Steinmann

British Journal of Pharmacology Vol. 168 No. 5 pp. 1059-1073 · Wiley

View at Publisher Save 10.1111/bph.12009

Abstract

The consumption of green tea (Camellia sinensis) has been shown to have many physiological and pharmacological health benefits. In the past two decades several studies have reported that epigallocatechin‐3‐gallate (EGCG), the main constituent of green tea, has anti‐infective properties. Antiviral activities of EGCG with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. Furthermore, the molecule interferes with the replication cycle of DNA viruses like hepatitis B virus, herpes simplex virus and adenovirus. Most of these studies demonstrated antiviral properties within physiological concentrations of EGCG in vitro. In contrast, the minimum inhibitory concentrations against bacteria were 10–100‐fold higher. Nevertheless, the antibacterial effects of EGCG alone and in combination with different antibiotics have been intensively analysed against a number of bacteria including multidrug‐resistant strains such as methicillin‐resistant Staphylococcus aureus or Stenotrophomonas maltophilia. Furthermore, the catechin EGCG has antifungal activity against human‐pathogenic yeasts like Candida albicans. Although the mechanistic effects of EGCG are not fully understood, there are results indicating that EGCG binds to lipid membranes and affects the folic acid metabolism of bacteria and fungi by inhibiting the cytoplasmic enzyme dihydrofolate reductase. This review summarizes the current knowledge and future perspectives on the antibacterial, antifungal and antiviral effects of the green tea constituent EGCG.

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Details

Published: Feb 20, 2013
Vol/Issue: 168(5)
Pages: 1059-1073
License: View

Authors

J

Jörg Steinmann

Institute of Medical Microbiology University Hospital Essen University of Duisburg‐Essen Essen Germany

J

J Buer

Institute of Medical Microbiology University Hospital Essen University of Duisburg‐Essen Essen Germany

T

T Pietschmann

Institute of Experimental Virology Twincore, Centre for Experimental and Clinical Infection Research Hannover Germany

E

E Steinmann

Institute of Experimental Virology Twincore, Centre for Experimental and Clinical Infection Research Hannover Germany

Cite This Article

Jörg Steinmann, J Buer, T Pietschmann, et al. (2013). Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea. British Journal of Pharmacology, 168(5), 1059-1073. https://doi.org/10.1111/bph.12009

Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea

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