The extracellular matrix as a key regulator of intracellular signalling networks

Jordan F Hastings; Joanna N Skhinas; Dirk Fey; David R Croucher; Thomas R Cox

doi:10.1111/bph.14195

journal article Open Access Apr 19, 2018

The extracellular matrix as a key regulator of intracellular signalling networks

Jordan F Hastings Joanna N Skhinas Dirk Fey David R Croucher Thomas R Cox

British Journal of Pharmacology Vol. 176 No. 1 pp. 82-92 · Wiley

View at Publisher Save 10.1111/bph.14195

Abstract

The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This complex, acellular entity is composed of hundreds of individual molecules whose assembly, architecture and biomechanical properties are critical to controlling the behaviour and phenotype of the different cell types residing within tissues. Cells are the basic unit of life and the core building block of tissues and organs. At their simplest, they follow a set of rules, governed by their genetic code and effected through the complex protein signalling networks that these genes encode. These signalling networks assimilate and process the information received by the cell to control cellular decisions that govern cell fate. The ECM is the biggest provider of external stimuli to cells and as such is responsible for influencing intracellular signalling dynamics. In this review, we discuss the inclusion of ECM as a central regulatory signalling sub‐network in computational models of cellular decision making, with a focus on its role in diseases such as cancer.Linked ArticlesThis article is part of a themed section on Translating the Matrix. To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v176.1/issuetoc

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Details

Published: Apr 19, 2018
Vol/Issue: 176(1)
Pages: 82-92
License: View

Authors

J

Jordan F Hastings

The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division Darlinghurst NSW 2010 Australia

J

Joanna N Skhinas

The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division Darlinghurst NSW 2010 Australia

D

Dirk Fey

Systems Biology Ireland University College Dublin Dublin 4 Ireland

D

David R Croucher

The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division Darlinghurst NSW 2010 Australia; St Vincent's Clinical School, Faculty of Medicine UNSW Sydney Kensington NSW 2010 Australia; School of Medicine and Medical Science University College Dublin Dublin 4 Ireland

T

Thomas R Cox

The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division Darlinghurst NSW 2010 Australia; St Vincent's Clinical School, Faculty of Medicine UNSW Sydney Kensington NSW 2010 Australia

Funding

National Health and Medical Research Council Award: APP1129766APP1148099

Susan G. Komen for the Cure Award: CCR17483294

Cancer Institute NSW Award: 13/FRL/1‐02CDF171105

Cite This Article

Jordan F Hastings, Joanna N Skhinas, Dirk Fey, et al. (2018). The extracellular matrix as a key regulator of intracellular signalling networks. British Journal of Pharmacology, 176(1), 82-92. https://doi.org/10.1111/bph.14195

The extracellular matrix as a key regulator of intracellular signalling networks

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