NO as a multimodal transmitter in the brain: discovery and current status

John Garthwaite

doi:10.1111/bph.14532

journal article Open Access Dec 05, 2018

NO as a multimodal transmitter in the brain: discovery and current status

John Garthwaite

British Journal of Pharmacology Vol. 176 No. 2 pp. 197-211 · Wiley

View at Publisher Save 10.1111/bph.14532

Abstract

NO operates throughout the brain as an intercellular messenger, initiating its varied physiological effects by activating specialized GC‐coupled receptors, resulting in the formation of cGMP. In line with the widespread expression of this pathway, NO participates in numerous different brain functions. This review gives an account of the discovery of NO as a signalling molecule in the brain, experiments that originated in the search for a mysterious cGMP‐stimulating factor released from central neurones when their NMDA receptors were stimulated, and summarizes the subsequent key steps that helped establish its status as a central transmitter. Currently, various modes of operation are viewed to underlie its diverse behaviour, ranging from very local signalling between synaptic partners (in the orthograde or retrograde directions) to a volume‐type transmission whereby NO synthesized by multiple synchronous sources summate spatially and temporally to influence intermingled neuronal or non‐neuronal cells, irrespective of anatomical connectivity.Linked ArticlesThis article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc

Topics

No keywords indexed for this article. Browse by subject →

References

133

[1]

10.1016/j.brainresrev.2010.03.003

[2]

10.1111/bph.13877

[3]

10.1111/bph.13884

[4]

10.1016/s0006-8993(96)01147-x

[5]

10.1073/pnas.74.8.3203

[6]

10.1038/nature09613

[7]

10.1111/jnc.12334

[8]

Bartus K. Garthwaite G.&Garthwaite J.(2007).Blood vessels signalling to neurones through nitric oxide. pp.25–26. 10.36866/pn.67.25

[9]

10.1371/journal.pone.0057292

[10]

10.1073/pnas.1013147107

[11]

Bath PM "Nitric oxide donors (nitrates), L‐arginine, or nitric oxide synthase inhibitors for acute stroke" Cochrane Database Syst Rev (2017)

[12]

10.1038/sj.jcbfm.9600068

[13]

10.1124/mol.59.1.54

[14]

10.1038/sj.bjp.0704687

[15]

10.1172/jci65928

[16]

10.2174/0929867323666160812145454

[17]

10.1177/0333102417737778

[18]

10.1016/0006-8993(76)90233-x

[19]

10.1016/s0306-4522(03)00217-3

[20]

10.1038/361031a0

[21]

10.1111/j.1471-4159.2007.04464.x

[22]

10.1016/0896-6273(91)90374-9

[23]

10.1038/351714a0

[24]

10.1073/pnas.87.2.682

[25]

10.1016/s0092-8674(00)81053-3

[26]

10.1016/0197-0186(86)90162-2

[27]

10.1038/nrendo.2017.69

[28]

10.1002/neu.480230915

[29]

10.1016/s0021-9258(19)41910-8

[30]

10.1016/0006-8993(78)90722-9

[31]

10.1111/j.1460-9568.1990.tb00396.x

[32]

10.1016/s0021-9258(17)41011-8

[33]

10.1111/j.1471-4159.1976.tb00304.x

[34]

10.1016/s0021-9258(18)33996-6

[35]

10.1523/jneurosci.19-19-j0004.1999

[36]

10.1073/pnas.91.10.4214

[37]

10.1002/cne.20054

[38]

10.1016/j.neuron.2012.03.028

[39]

10.1016/j.niox.2017.09.001

[40]

10.1111/j.1471-4159.1974.tb06890.x

[41]

10.1146/annurev.ph.56.030194.001321

[42]

10.1111/gbb.12193

[43]

10.1523/jneurosci.20-17-06694.2000

[44]

10.1016/j.neuron.2008.01.034

[45]

10.1038/288373a0

[46]

10.1073/pnas.87.9.3547

[47]

10.1523/jneurosci.1528-06.2006

[48]

10.1002/glia.22759

[49]

10.1016/0306-4522(82)90209-3

[50]

10.1111/j.1476-5381.1985.tb08860.x

Showing 50 of 133 references

Cited By

95

The Unexpected Role of the Endothelial Nitric Oxide Synthase at the Neurovascular Unit: Beyond the Regulation of Cerebral Blood Flow

Giorgia Scarpellino, Valentina Brunetti · 2024

International Journal of Molecular...

Electro-metabolic signaling

Thomas A. Longden, W. Jonathan Lederer · 2024

Journal of General Physiology

Effect of Activation and Blockade of Nitrergic Neurotransmission on Serotonin System Activity of the Rat Medial Prefrontal Cortex

N. B. Saulskaya, M. A. Burmakina · 2022

Journal of Evolutionary Biochemistr...

Nitric oxide signaling in health and disease

Jon O. Lundberg, Eddie Weitzberg · 2022

Cell

Role of hippocampal nitrergic neurotransmission in behavioral and cardiovascular dysfunctions evoked by chronic social stress

Jeferson Almeida, Leandro A. Oliveira · 2020

Nitric Oxide

Differential roles of hippocampal nNOS and iNOS in the control of baroreflex function in conscious rats

Jeferson Almeida, Leandro A. Oliveira · 2019

Brain Research

Metrics

95

Citations

133

References

Details

Published: Dec 05, 2018
Vol/Issue: 176(2)
Pages: 197-211
License: View

Authors

J

John Garthwaite

Wolfson Institute for Biomedical Research University College London London UK

Funding

Wellcome Trust

Cite This Article

John Garthwaite (2018). NO as a multimodal transmitter in the brain: discovery and current status. British Journal of Pharmacology, 176(2), 197-211. https://doi.org/10.1111/bph.14532

NO as a multimodal transmitter in the brain: discovery and current status

You May Also Like