The Staufen1‐dependent cell cycle regulon or how a misregulated RNA‐binding protein leads to cancer

Florence Bonnet‐Magnaval; Luc DesGroseillers

doi:10.1111/brv.12749

journal article May 20, 2021

The Staufen1‐dependent cell cycle regulon or how a misregulated RNA‐binding protein leads to cancer

Florence Bonnet‐Magnaval Luc DesGroseillers

Biological Reviews Vol. 96 No. 5 pp. 2192-2208 · Wiley

View at Publisher Save 10.1111/brv.12749

Abstract

ABSTRACTIn recent years, an increasing number of reports have linked the RNA‐binding protein Staufen1 (STAU1) to the control of cell decision making. In non‐transformed cells, STAU1 balances the expression of messenger RNA (mRNA) regulons that regulate differentiation and well‐ordered cell division. Misregulation of STAU1 expression and/or functions changes the fragile balance in the expression of pro‐ and anti‐proliferative and apoptotic genes and favours a novel equilibrium that supports cell proliferation and cancer development. The misregulation of STAU1 functions causes multiple coordinated modest effects in the post‐transcriptional regulation of many RNA targets that code for cell cycle regulators, leading to dramatic consequences at the cellular level. The new tumorigenic equilibrium in STAU1‐mediated gene regulation observed in cancer cells can be further altered by a slight increase in STAU1 expression that favours expression of pro‐apoptotic genes and cell death. The STAU1‐dependent cell cycle regulon is a good model to study how abnormal expression of an RNA‐binding protein promotes cell growth and provides an advantageous selection of malignant cells in the first step of cancer development.

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Details

Published: May 20, 2021
Vol/Issue: 96(5)
Pages: 2192-2208
License: View

Authors

F

Florence Bonnet‐Magnaval

Département de biochimie et médecine moléculaire, Faculté de médecine Université de Montréal 2900 Édouard Montpetit Montréal QC H3T 1J4 Canada

L

Luc DesGroseillers

Département de biochimie et médecine moléculaire, Faculté de médecine Université de Montréal 2900 Édouard Montpetit Montréal QC H3T 1J4 Canada

Cite This Article

Florence Bonnet‐Magnaval, Luc DesGroseillers (2021). The Staufen1‐dependent cell cycle regulon or how a misregulated RNA‐binding protein leads to cancer. Biological Reviews, 96(5), 2192-2208. https://doi.org/10.1111/brv.12749

The Staufen1‐dependent cell cycle regulon or how a misregulated RNA‐binding protein leads to cancer

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