Extracellular vesicles as trans‐genomic agents: Emerging roles in disease and evolution

Yumi Kawamura; Yusuke Yamamoto; Taka‐Aki Sato; Takahiro Ochiya

doi:10.1111/cas.13222

journal article Open Access May 01, 2017

Extracellular vesicles as trans‐genomic agents: Emerging roles in disease and evolution

Yumi Kawamura

Yusuke Yamamoto

Taka‐Aki Sato Takahiro Ochiya

Cancer Science Vol. 108 No. 5 pp. 824-830 · Wiley

View at Publisher Save 10.1111/cas.13222

Abstract

The composition of genetic material in extracellular vesicles (EV) has sparked interest particularly in the potential for horizontal gene transfer by EV. Although the RNA content of EV has been studied extensively, few reports have examined the DNA content of EV. It is still unclear how DNA is packaged inside EV, and whether they are functional in recipient cells. In this review, we describe the biological significance of genetic material in EV and their possible impacts in recipient cells, with focus on DNA from cancer cell‐derived EV and the potential roles they may play in the cancer microenvironment. Another important feature of the genetic content of EV is the presence of retrotransposon elements. In this review, we discuss the possibility of an EV‐mediated mechanism for the dispersal of retrotransposon elements, and their potential involvement in the development of genetically influenced diseases. In addition to this, we discuss the potential involvement of EV in the transfer of genetic material across species, and their possible impacts in modulating genome evolution.

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Details

Published: May 01, 2017
Vol/Issue: 108(5)
Pages: 824-830
License: View

Authors

Y

Yumi Kawamura

Division of Molecular and Cellular Medicine National Cancer Center Research Institute Tokyo Japan; Ph.D. Program in Human Biology School of Integrative and Global Majors University of Tsukuba Tsukuba Japan

Y

Yusuke Yamamoto

Division of Molecular and Cellular Medicine National Cancer Center Research Institute Tokyo Japan

T

Taka‐Aki Sato

Ph.D. Program in Human Biology School of Integrative and Global Majors University of Tsukuba Tsukuba Japan

T

Takahiro Ochiya

Division of Molecular and Cellular Medicine National Cancer Center Research Institute Tokyo Japan

Funding

Japan Agency for Medical Research and Development

New Energy and Industrial Technology Development Organization

Cite This Article

Yumi Kawamura, Yusuke Yamamoto, Taka‐Aki Sato, et al. (2017). Extracellular vesicles as trans‐genomic agents: Emerging roles in disease and evolution. Cancer Science, 108(5), 824-830. https://doi.org/10.1111/cas.13222

Extracellular vesicles as trans‐genomic agents: Emerging roles in disease and evolution

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