Retinal microvasculature and choriocapillaris impairments according to the stage of dry age‐related macular degeneration

Jung‐Tae Kim; Ji‐Ho Jun; Sung‐Chul Lee; Min‐Woo Lee

doi:10.1111/ceo.14165

journal article Sep 16, 2022

Retinal microvasculature and choriocapillaris impairments according to the stage of dry age‐related macular degeneration

Jung‐Tae Kim Ji‐Ho Jun Sung‐Chul Lee Min‐Woo Lee

Clinical & Experimental Ophthalmology Vol. 51 No. 1 pp. 36-43 · Wiley

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Abstract

AbstractBackgroundWe aimed to analyse the retinal microvasculature and choriocapillaris according to the dry age‐related macular degeneration (AMD) stage and to identify factors associated with their microvasculatures.MethodsPatients were divided into four groups: normal controls, early, intermediate and advanced AMD groups. The vessel density (VD) of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris was compared using optical coherence tomography angiography among the groups. Linear regression analysis was performed to identify factors associated with the VD.ResultsThe VDs of the SCP were 22.1 ± 5.7, 19.1 ± 5.4, 18.0 ± 6.4 and 12.2 ± 6.4% (p < 0.001); the VDs of the DCP were 22.4 ± 4.5, 20.7 ± 4.3, 18.1 ± 5.3 and 14.6 ± 5.8% (p < 0.001); the VDs of the choriocapillaris were 29.4 ± 3.7, 26.4 ± 4.8, 24.5 ± 4.9 and 24.2 ± 3.7% (p < 0.001) in the control, early, intermediate, and advanced groups, respectively. AMD stage and age were significantly associated with the VDs of all layers, and the VDs of the SCP and DCP were associated with visual acuity (both p < 0.001). Additionally, hypertension was associated with the VDs of the DCP (p = 0.027) and choriocapillaris (p = 0.024).ConclusionsThe retinal microvasculature and choriocapillaris tended to become more impaired as the AMD stage progressed. Age was significantly associated with the microvasculature impairments of all layers, and hypertension was significantly associated with impairments of the DCP microvasculature and choriocapillaris.

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Details

Published: Sep 16, 2022
Vol/Issue: 51(1)
Pages: 36-43
License: View

Authors

J

Jung‐Tae Kim

Department of Ophthalmology Konyang University College of Medicine Daejeon Republic of Korea

J

Ji‐Ho Jun

Department of Ophthalmology Konyang University College of Medicine Daejeon Republic of Korea

S

Sung‐Chul Lee

Department of Ophthalmology Konyang University College of Medicine Daejeon Republic of Korea

M

Min‐Woo Lee

Department of Ophthalmology Konyang University College of Medicine Daejeon Republic of Korea

Cite This Article

Jung‐Tae Kim, Ji‐Ho Jun, Sung‐Chul Lee, et al. (2022). Retinal microvasculature and choriocapillaris impairments according to the stage of dry age‐related macular degeneration. Clinical & Experimental Ophthalmology, 51(1), 36-43. https://doi.org/10.1111/ceo.14165

Retinal microvasculature and choriocapillaris impairments according to the stage of dry age‐related macular degeneration

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