Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

Yanwei You; Yang Zhang; Xingtian Li; Xinming Li; Xindong Ma

doi:10.1111/cns.14783

journal article Open Access May 01, 2024

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

Yanwei You

Yang Zhang

Xingtian Li Xinming Li

Xindong Ma

CNS Neuroscience & Therapeutics Vol. 30 No. 5 · Wiley

View at Publisher Save 10.1111/cns.14783

Abstract

AbstractAimsThe molecular mechanism of short‐sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011–2014) and explore cellular mechanisms in mice.MethodsSystemic immune‐inflammation index (SII) was calculated using blood‐cell based biomarkers. Further, we employed integrated bioinformatics and single‐cell transcriptomics (GSE137665) to examine how short sleep exposure influenced the molecular pathways associated with inflammation in the brain. To explore the signaling pathways and biological processes of sleep deprivation, we carried out enrichment analyses utilizing the GO and KEGG databases.ResultsPopulation results showed that, compared with normal sleep group, severe short sleep was associated with lower cognitive ability in all the four tests. Moreover, a higher SII level was correlated with lower scores of cognitive tests. In mice study, elevated activation of the inflammatory pathway was observed in cell subgroups of neurons within the sleep deprivation and recovery sleep cohorts. Additionally, heightened expression of oxidative stress and integrated stress response pathways was noted in GABAergic neurons during sleep deprivation.ConclusionThis study contributed to the understanding of the influence of short sleep on cognitive function and its cellular mechanisms.

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Details

Published: May 01, 2024
Vol/Issue: 30(5)
License: View

Authors

Y

Yanwei You

Division of Sports Science & Physical Education Tsinghua University Beijing China; IDG/McGovern Institute for Brain Research Tsinghua University Beijing China

Y

Yang Zhang

Department of Vascular Surgery Fuwai Yunnan Cardiovascular Hospital, Affiliated Cardiovascular Hospital of Kunming Medical University Kunming China

X

Xingtian Li

Division of Sports Science & Physical Education Tsinghua University Beijing China; IDG/McGovern Institute for Brain Research Tsinghua University Beijing China

X

Xinming Li

Division of Sports Science & Physical Education Tsinghua University Beijing China; IDG/McGovern Institute for Brain Research Tsinghua University Beijing China

X

Xindong Ma

Division of Sports Science & Physical Education Tsinghua University Beijing China; IDG/McGovern Institute for Brain Research Tsinghua University Beijing China

Cite This Article

Yanwei You, Yang Zhang, Xingtian Li, et al. (2024). Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies. CNS Neuroscience & Therapeutics, 30(5). https://doi.org/10.1111/cns.14783

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

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