Advances in the study of the glymphatic system and aging

Ying Xiong; Qingying Yu; Haimei Zhi; Huiyuan Peng; Kejian Li; Yuexiang Ma; Peng Sun

doi:10.1111/cns.14803

journal article Open Access Jun 01, 2024

Advances in the study of the glymphatic system and aging

Ying Xiong

Qingying Yu

Haimei Zhi Huiyuan Peng Kejian Li

Yuexiang Ma Peng Sun

CNS Neuroscience & Therapeutics Vol. 30 No. 6 · Wiley

View at Publisher Save 10.1111/cns.14803

Abstract

AbstractThe glymphatic system is cerebrospinal fluid–brain tissue fluid exchange flow mediated by aquaporin‐4 (AQP4) on the end feet of astrocytes for a system, which is capable of rapidly removing brain metabolites and thus maintaining brain homeostasis, and is known as the central immune system. Dysfunction of the glymphatic system causes accumulation of misfolded and highly phosphorylated proteins (amyloid‐β and Tau proteins), which destabilizes the proteins, and the body's neuroinflammatory factors are altered causing aging of the immune system and leading to neurodegenerative diseases. Damage to the glymphatic system and aging share common manifestations, as well as unstudied biological mechanisms that are also linked, such as mitochondria, oxidative stress, chronic inflammation, and sleep. In this paper, we first summarize the structure, function, and research methods of the glymphatic system and the relationship between the glymphatic system and the peripheral immune system, and second, sort out and summarize the factors of the glymphatic system in removing metabolites and resolving aging‐related diseases and factors affecting aging, to explore its related biological mechanisms, and moreover, to provide a new way of thinking for treating or intervening aging‐related diseases.

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Details

Published: Jun 01, 2024
Vol/Issue: 30(6)
License: View

Authors

Y

Ying Xiong

School of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan China

Q

Qingying Yu

Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine Guangzhou China

H

Haimei Zhi

Qilu Hospital of Shandong University Jinan China

H

Huiyuan Peng

Department of Rehabilitation Zhongshan Hospital of Traditional Chinese Medicine Zhongshan China

K

Kejian Li

Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine Jinan China

Y

Yuexiang Ma

School of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan China

P

Peng Sun

Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine Jinan China

Funding

National Natural Science Foundation of China Award: 81303074

Key Technology Research and Development Program of Shandong Province Award: 2022CXGC020514

Natural Science Foundation of Shandong Province Award: ZR2019MH063

Cite This Article

Ying Xiong, Qingying Yu, Haimei Zhi, et al. (2024). Advances in the study of the glymphatic system and aging. CNS Neuroscience & Therapeutics, 30(6). https://doi.org/10.1111/cns.14803

Advances in the study of the glymphatic system and aging

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