Concomitant positive patch test reactions in FreeStyle‐allergic patients sensitized to isobornyl acrylate

Ella Dendooven; Kenn Foubert; An Goossens; Philippe Gilles; Wim De Borggraeve; Luc Pieters; Julien Lambert; Olivier Aerts

doi:10.1111/cod.13706

journal article Oct 13, 2020

Concomitant positive patch test reactions in FreeStyle‐allergic patients sensitized to isobornyl acrylate

Ella Dendooven Kenn Foubert

An Goossens

Philippe Gilles Wim De Borggraeve

Luc Pieters

Julien Lambert Olivier Aerts

Contact Dermatitis Vol. 84 No. 3 pp. 166-174 · Wiley

View at Publisher Save 10.1111/cod.13706

Abstract

AbstractBackgroundConcomitant positive patch test reactions in patients sensitized to isobornyl acrylate (IBOA) have rarely been documented.ObjectivesTo report concomitant sensitizations in patients with allergic contact dermatitis (ACD) from the glucose sensor FreeStyle Libre and sensitized to IBOA.MethodsIn 2019, 26 patients with suspected ACD from FreeStyle Libre were patch tested to a baseline series and to a (meth) acrylate series containing IBOA and 2‐phenoxyethyl acrylate (PEA) 0.1% pet. Diabetes devices and patch test preparations were analyzed with gas chromatography – mass spectrometry (GC‐MS) for the presence of IBOA and PEA.ResultsOf the 26 patients, 18 (69%) were sensitized to IBOA, and eight (44%) and 11 (61%) of these were co‐sensitized to sesquiterpene lactones and fragrances, respectively. Ten patients (56%) were co‐sensitized to PEA, which, contrary to IBOA, could not be detected in any device. The PEA test material was shown to be contaminated with IBOA.ConclusionsContact allergy to IBOA appears to be declining and IBOA‐sensitized patients are most often co‐sensitized to sesquiterpene lactones and fragrances. Vigilance is required when patch testing (acrylate) materials obtained from industry, as these might be contaminated and, hence, alter the results and their interpretation.

Topics

No keywords indexed for this article. Browse by subject →

References

27

[1]

10.1111/cod.13120

[2]

10.1111/cod.12866

[3]

10.1097/der.0000000000000549

[4]

10.2337/dc19-1354

[5]

European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice

Jeanne D. Johansen, Kristiina Aalto‐Korte, Tove Agner et al.

Contact Dermatitis 10.1111/cod.12432

[6]

10.1111/cod.13248

[7]

Allergic contact dermatitis caused by isobornyl acrylate in the Enlite glucose sensor and the Paradigm MiniMed Quick‐set insulin infusion set

Anne Herman, Marie Baeck, Laurence de Montjoye et al.

Contact Dermatitis 10.1111/cod.13374

[8]

Allergic contact dermatitis and diabetes medical devices: 2 clinical cases

Stefano Passanisi, Fortunato Lombardo, Andrea Barbalace et al.

Contact Dermatitis 10.1111/cod.13012

[9]

10.1177/1932296818762946

[10]

Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump

Nadia Raison‐Peyron, M. Mowitz, Nathalie Bonardel et al.

Contact Dermatitis 10.1111/cod.12995

[11]

10.1111/cod.13337

[12]

Contact dermatitis caused by glucose sensors—15 adult patients tested with a medical device patch test series

J. Ulriksdotter, Cecilia Svedman, M. Bruze et al.

Contact Dermatitis 10.1111/cod.13649

[13]

10.1111/cod.13243

[14]

10.1016/s0140-6736(17)32142-6

[15]

10.1111/cod.13529

[16]

10.1111/cod.13075

[17]

10.1111/j.1600-0536.2010.01760.x

[18]

10.1111/j.1600-0536.1996.tb02305.x

[19]

Contact allergy to components of glue in insulin pump infusion sets

A. M. Busschots, V. Meuleman, N. Poesen et al.

Contact Dermatitis 10.1111/j.1600-0536.1995.tb00554.x

[20]

10.1034/j.1600-0536.2001.045001036.x

[21]

10.1111/j.1600-0536.2008.01333.x

[22]

10.1111/j.1600-0536.2009.01574.x

[23]

10.1111/cod.13330

[24]

10.1111/j.1365-2133.1978.tb01977.x

[25]

10.1111/cod.13155

[26]

10.2340/00015555-3256

[27]

10.1039/np9890600291

Cited By

30

Patch Testing in Individuals With Diabetes Using Medical Devices. Part 1—Contact Allergy to Baseline Series Allergens

Thanisorn Sukakul, J. Ulriksdotter · 2026

Contact Dermatitis

1,6‐Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors

Ella Dendooven, Fleur Haentjens · 2025

Contact Dermatitis

Metrics

30

Citations

27

References

Details

Published: Oct 13, 2020
Vol/Issue: 84(3)
Pages: 166-174
License: View

Authors

E

Ella Dendooven

Department of Dermatology University Hospital Antwerp (UZA) Antwerp Belgium; Research Group Immunology, Infla‐Med Centre of Excellence University of Antwerp Antwerp Belgium; Research Group Natural Products and Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA) Antwerp Belgium

K

Kenn Foubert

Research Group Natural Products and Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA) Antwerp Belgium

A

An Goossens

Department of Dermatology University Hospitals KU Leuven Leuven Belgium

P

Philippe Gilles

Molecular Design and Synthesis, Department of Chemistry KU Leuven Leuven Belgium

W

Wim De Borggraeve

Molecular Design and Synthesis, Department of Chemistry KU Leuven Leuven Belgium

L

Luc Pieters

Research Group Natural Products and Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA) Antwerp Belgium

J

Julien Lambert

Department of Dermatology University Hospital Antwerp (UZA) Antwerp Belgium; Research Group Immunology, Infla‐Med Centre of Excellence University of Antwerp Antwerp Belgium

O

Olivier Aerts

Department of Dermatology University Hospital Antwerp (UZA) Antwerp Belgium; Research Group Immunology, Infla‐Med Centre of Excellence University of Antwerp Antwerp Belgium

Cite This Article

Ella Dendooven, Kenn Foubert, An Goossens, et al. (2020). Concomitant positive patch test reactions in FreeStyle‐allergic patients sensitized to isobornyl acrylate. Contact Dermatitis, 84(3), 166-174. https://doi.org/10.1111/cod.13706

Concomitant positive patch test reactions in FreeStyle‐allergic patients sensitized to isobornyl acrylate

You May Also Like