Isocyanates may contribute to allergic contact dermatitis from diabetes devices and wound dressings

Ella Dendooven; Kenn Foubert; Tania Naessens; Luc Pieters; Julien Lambert; Olivier Aerts

doi:10.1111/cod.14187

journal article Jul 21, 2022

Isocyanates may contribute to allergic contact dermatitis from diabetes devices and wound dressings

Ella Dendooven Kenn Foubert

Tania Naessens Luc Pieters

Julien Lambert Olivier Aerts

Contact Dermatitis Vol. 87 No. 5 pp. 414-419 · Wiley

View at Publisher Save 10.1111/cod.14187

Abstract

AbstractBackgroundIsocyanates are well‐known occupational allergens, but can also be present in medical devices.ObjectivesTo highlight that contact sensitization to isocyanates might contribute to allergic contact dermatitis (ACD) from polyurethane (PU)‐containing diabetes devices and wound dressings.Patients and MethodsNineteen patients with suspected ACD from diabetes devices and/or wound dressings were patch tested to an isocyanate series. Four wound dressings, six diabetes devices and four monomeric isocyanate patch test preparations were analysed with gas chromatography – mass spectrometry.ResultsEight patients reacted to isocyanates and corresponding amines: 3 to isophorone diisocyanate (IPDI), 4 to 4,4′‐diaminodiphenylmethane (MDA), 4 to 2,4‐toluene diisocyanate (TDI) and 1 to polymeric methylene diphenyl diisocyanate (PMDI). Three of four wound dressings contained isocyanates (methylene diphenyl diisocyanate [MDI], TDI and/or IPDI), whereas five of six diabetes devices contained 4,4′‐MDI, and one of them also IPDI. None of the medical devices contained 1,6‐hexamethylene diisocyanate. Contrary to IPDI, and especially MDI, only the concentration of the TDI patch test preparation corresponded approximately (80%) to its label.ConclusionPatch tests with isocyanates may be worth‐while in patients with suspected ACD from PU‐containing medical devices. Besides MDA, and PMDI, also TDI might potentially be a marker for MDI‐sensitization.

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Metrics

22

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17

References

Details

Published: Jul 21, 2022
Vol/Issue: 87(5)
Pages: 414-419
License: View

Authors

E

Ella Dendooven

Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA‐MED Centre of Excellence, University of Antwerp Antwerp Belgium; Research Group Natural Products & Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp Antwerp Belgium

K

Kenn Foubert

Research Group Natural Products & Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp Antwerp Belgium

T

Tania Naessens

Research Group Natural Products & Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp Antwerp Belgium

L

Luc Pieters

Research Group Natural Products & Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp Antwerp Belgium

J

Julien Lambert

Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA‐MED Centre of Excellence, University of Antwerp Antwerp Belgium

O

Olivier Aerts

Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA‐MED Centre of Excellence, University of Antwerp Antwerp Belgium

Cite This Article

Ella Dendooven, Kenn Foubert, Tania Naessens, et al. (2022). Isocyanates may contribute to allergic contact dermatitis from diabetes devices and wound dressings. Contact Dermatitis, 87(5), 414-419. https://doi.org/10.1111/cod.14187

Isocyanates may contribute to allergic contact dermatitis from diabetes devices and wound dressings

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