2‐Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis—Part 1. Introduction, epidemiology, case series and case reports

Anton C. de Groot; Thomas Rustemeyer

doi:10.1111/cod.14405

journal article Sep 26, 2023

2‐Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis—Part 1. Introduction, epidemiology, case series and case reports

Anton C. de Groot

Thomas Rustemeyer

Contact Dermatitis Vol. 89 No. 6 pp. 401-433 · Wiley

View at Publisher Save 10.1111/cod.14405

Abstract

Abstract2‐Hydroxyethyl methacrylate (HEMA) has been increasingly recognised as a contact allergen and was added to the European baseline series in 2019. In this article (2 parts), the results of an extensive literature review of the clinical aspects of contact allergy/allergic contact dermatitis to HEMA are presented. In part 1, the epidemiology of HEMA contact allergy is discussed and detailed information on published case series and case reports presented. HEMA is an important cause of contact allergy/allergic contact dermatitis in North America and Europe with recent prevalences of >3% in the USA + Canada and 1.5%–3.7% in Europe. Currently, most cases are caused by nail cosmetics, both in consumers and professional nail stylists. In our literature review, we have found 24 studies presenting case series of patients with allergic contact dermatitis attributed to HEMA and 168 case reports. However, the presence of HEMA in the products causing ACD was established in only a minority. Part 2 will discuss cross‐ and co‐sensitisation, and other skin reactions to HEMA, will assess whether HEMA is the most frequent (meth)acrylate allergen and how sensitive HEMA as a screening agent is, investigate the presence of HEMA in commercial products and provide practical information on patch testing procedures.

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Details

Published: Sep 26, 2023
Vol/Issue: 89(6)
Pages: 401-433
License: View

Authors

A

Anton C. de Groot

Schipslootweg 5 Wapserveen The Netherlands

T

Thomas Rustemeyer

Dermato‐Allergology and Occupational Dermatology Amsterdam University Medical Centers Amsterdam AZ The Netherlands

Cite This Article

Anton C. de Groot, Thomas Rustemeyer (2023). 2‐Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis—Part 1. Introduction, epidemiology, case series and case reports. Contact Dermatitis, 89(6), 401-433. https://doi.org/10.1111/cod.14405

2‐Hydroxyethyl methacrylate (HEMA): A clinical review of contact allergy and allergic contact dermatitis—Part 1. Introduction, epidemiology, case series and case reports

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