Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature

Tariq Al‐Zaid; Gretchen Frieling; Seth Rosenthal

doi:10.1111/cup.12164

journal article May 08, 2013

Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature

Tariq Al‐Zaid Gretchen Frieling Seth Rosenthal

Journal of Cutaneous Pathology Vol. 40 No. 8 pp. 734-739 · Wiley

View at Publisher Save 10.1111/cup.12164

Abstract

Pleomorphic liposarcoma (PLPS) is a rare, high‐grade sarcoma defined by the presence of pleomorphic lipoblasts. Constituting 5% of all liposarcomas, PLPS usually arises in deep soft tissues of the extremities, with rare occurrences in the dermis and subcutis. We describe a unique case of an 85‐year‐old Caucasian gentleman with a 1 year history of a pedunculated, pink, non‐tender papule on the dorsum of his left arm, measuring 1.0 cm in maximum dimension. Biopsy revealed a dermal collection of atypical epithelioid and spindle cells superimposed on a sclerotic background, resembling a pleomorphic fibroma on low power. On high power, a central focus of discrete adipocytic differentiation with pleomorphic lipoblasts was present. Tumor cells were positive for S‐100 and negative for desmin, actin, CD68, keratin, MART‐1 and CD34. Clinicopathologic findings were consistent with PLPS and the diagnosis was made. PLPS is rarely localized to the dermis and one with low power features resembling a pleomorphic fibroma has not been previously described in the literature.

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Metrics

12

Citations

22

References

Details

Published: May 08, 2013
Vol/Issue: 40(8)
Pages: 734-739
License: View

Authors

T

Tariq Al‐Zaid

Department of Pathology Tufts Medical Center Boston MA USA

G

Gretchen Frieling

Department of Pathology Beth Israel Deaconess Medical Center Boston MA USA

S

Seth Rosenthal

Department of Dermatopathology Caris Life Sciences Newton MA USA

Cite This Article

Tariq Al‐Zaid, Gretchen Frieling, Seth Rosenthal (2013). Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. Journal of Cutaneous Pathology, 40(8), 734-739. https://doi.org/10.1111/cup.12164

Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature

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