Unusual Cytology Features of A
                    
                      DICER1
                    
                    ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Wenli Dai; Eduardo V. Zambrano; Sabri Yilmaz; Qian Wang

doi:10.1111/cyt.70053

journal article Open Access Jan 20, 2026

Unusual Cytology Features of A DICER1 ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Wenli Dai Eduardo V. Zambrano

Sabri Yilmaz Qian Wang

Cytopathology Vol. 37 No. 3 pp. 300-303 · Wiley

View at Publisher Save 10.1111/cyt.70053

Abstract

ABSTRACT

DICER1
‐mutated thyroid lesions can range from indolent to aggressive neoplasms. Infarction has been recently described as a histologic feature of
DICER1
‐mutated thyroid nodules. In this case report, we presented a
DICER1
‐mutated nodule which presented predominantly with debris in the fine needle aspiration (FNA) specimen and was confirmed on surgical resection to be a near total infarcted nodule. To the best of our knowledge, this is the first cytopathology report of a
DICER1
‐mutated thyroid lesion presenting as an infarcted nodule. Awareness of the features described herein may help prevent both overdiagnosis and underdiagnosis in the evaluation of thyroid nodules via FNA.

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Citations

10

References

Details

Published: Jan 20, 2026
Vol/Issue: 37(3)
Pages: 300-303
License: View

Authors

W

Wenli Dai

Department of Pathology University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA; School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA

E

Eduardo V. Zambrano

Department of Pathology and Laboratory Medicine Phoenix Children's Hospital Phoenix Arizona USA; Department of Child Health University of Arizona College of Medicine Phoenix Arizona USA; Department of Pathology Creighton University School of Medicine Phoenix Arizona USA

S

Sabri Yilmaz

School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA; Department of Radiology UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA

Q

Qian Wang

School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA; Department of Pathology UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA

Cite This Article

Wenli Dai, Eduardo V. Zambrano, Sabri Yilmaz, et al. (2026). Unusual Cytology Features of A DICER1 ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration. Cytopathology, 37(3), 300-303. https://doi.org/10.1111/cyt.70053

Unusual Cytology Features of A DICER1 ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

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