Liver holidays? A meta‐analysis of drinking the same amount of alcohol daily or non‐daily and the risk for cirrhosis

Laura Llamosas‐Falcón; Alexander Tran; Huan Jiang; Jürgen Rehm

doi:10.1111/dar.13563

journal article Oct 24, 2022

Liver holidays? A meta‐analysis of drinking the same amount of alcohol daily or non‐daily and the risk for cirrhosis

Laura Llamosas‐Falcón

Alexander Tran

Huan Jiang

Jürgen Rehm

Drug and Alcohol Review Vol. 42 No. 1 pp. 119-124 · Wiley

View at Publisher Save 10.1111/dar.13563

Abstract

AbstractIntroductionSeveral alcohol drinking guidelines indicate that daily alcohol consumption should be avoided because of its negative impact on the liver and to avoid the development of alcohol use disorders. Evidence that supports this recommendation is scarce. Our aim was to compare daily versus non‐daily drinking and its association with liver cirrhosis.MethodsWe conducted a review using PubMed/Medline and Embase as databases, selecting longitudinal or case control studies. A random effects meta‐analysis was conducted.ResultsFive mainly large‐scale studies were retrieved. Daily drinking was associated with a significant increase in risk of liver cirrhosis compared to non‐daily drinking, with a pooled relative risks of 1.71 (95% confidence interval 1.23–2.23) for men and 1.56 (95% confidence interval 1.39–1.74) for women.Discussion and ConclusionsThe consistent exposure to acetaldehyde and other toxins for daily drinkers may explain our findings. There should be days of abstinence to allow the liver to recover, especially for heavier drinkers.

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Metrics

8

Citations

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References

Details

Published: Oct 24, 2022
Vol/Issue: 42(1)
Pages: 119-124
License: View

Authors

L

Laura Llamosas‐Falcón

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health Toronto Canada

A

Alexander Tran

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health Toronto Canada

H

Huan Jiang

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health Toronto Canada; Dalla Lana School of Public Health University of Toronto Toronto Canada

J

Jürgen Rehm

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health Toronto Canada; Dalla Lana School of Public Health University of Toronto Toronto Canada; Institute of Clinical Psychology and Psychotherapy and Center of Clinical Epidemiology and Longitudinal Studies Technische Universität Dresden Dresden Germany; World Health Organization/Pan American Health Organization Collaborating Centre, Centre for Addiction and Mental Health Toronto Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto Canada

Cite This Article

Laura Llamosas‐Falcón, Alexander Tran, Huan Jiang, et al. (2022). Liver holidays? A meta‐analysis of drinking the same amount of alcohol daily or non‐daily and the risk for cirrhosis. Drug and Alcohol Review, 42(1), 119-124. https://doi.org/10.1111/dar.13563

Liver holidays? A meta‐analysis of drinking the same amount of alcohol daily or non‐daily and the risk for cirrhosis

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