Cutaneous B‐cell lymphomas – pathogenesis, diagnostic workup, and therapy

Jan P. Nicolay; Marion Wobser

doi:10.1111/ddg.13164

journal article Dec 01, 2016

Cutaneous B‐cell lymphomas – pathogenesis, diagnostic workup, and therapy

Jan P. Nicolay Marion Wobser

JDDG: Journal der Deutschen Dermatologischen Gesellschaft Vol. 14 No. 12 pp. 1207-1224 · Wiley

View at Publisher Save 10.1111/ddg.13164

Abstract

SummaryCutaneous B‐cell lymphomas (CBCLs) comprise a group of mature lymphoproliferative B‐cell disorders that primarily affect the skin. Characterized by great biological and clinical variability among its various subtypes, CBCLs fundamentally differ from primary nodal or systemic B‐cell lymphomas. Given their uncomplicated course and excellent prognosis, lymphoma classifications rank primary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous follicle center lymphoma (PCFCL) as indolent CBCLs. By contrast, diffuse large B‐cell lymphoma, leg type (DLBCL‐LT) in particular, represent more aggressive lymphoma variants associated with a poorer prognosis. Therapeutic decisions and diagnostic procedures are based on the exact histological and immunohistochemical classification as well as the exclusion of systemic involvement and thus differentiation from nodal and systemic lymphomas. In this context, the diagnostic workup should also include molecular biology methods. Primary therapeutic options for indolent CBCL lesions include surgery and radiation therapy, as well as systemic treatment with rituximab (anti‐CD20 antibody) in case of dissemination. More aggressive CBCLs usually require a combination of rituximab and polychemotherapy, primarily the CHOP regimen or modifications thereof. Given that the pathogenesis and biology of CBCLs has not been conclusively elucidated, and given the limited therapeutic armamentarium available, there is great need for comprehensive research, especially with respect to DLBCL‐LT.

Topics

No keywords indexed for this article. Browse by subject →

References

45

[1]

10.1111/ddg.12237_suppl

[2]

10.1097/cco.0000000000000060

[3]

10.1111/j.1610-0387.2011.07852_suppl.x

[4]

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Steven H. Swerdlow, Elias Campo, Stefano A. Pileri et al.

Blood 10.1182/blood-2016-01-643569

[5]

10.1200/jco.2006.09.6396

[6]

10.1182/blood-2005-09-3679

[7]

10.1097/dad.0b013e31804795a6

[8]

10.1038/jid.2008.243

[9]

10.1111/bjd.13960

[10]

10.1182/blood-2006-10-054601

[11]

10.1590/abd1806-4841.20153638

[12]

10.1016/j.jaad.2013.06.012

[13]

10.1038/modpathol.2013.106

[14]

10.1097/dad.0b013e318289b20e

[15]

10.1182/blood-2008-04-152850

[16]

10.1002/ajh.23863

[17]

10.1111/j.1365-2141.2008.07159.x

[18]

10.1111/ddg.12015_5

[19]

10.1001/archderm.143.12.1520

[20]

10.1016/j.ijrobp.2015.01.008

[21]

10.1016/j.jaad.2013.11.019

[22]

10.1111/j.1365-2133.2012.10902.x

[23]

10.1016/j.jdcr.2016.07.006

[24]

10.1080/10428190802258923

[25]

10.1111/j.1749-6632.2012.06661.x

[26]

10.1111/bjh.13764

[27]

10.1111/bjd.12484

[28]

10.1001/jamadermatol.2014.821

[29]

10.1182/blood-2003-05-1545

[30]

10.1001/jamadermatol.2013.7452

[31]

10.1182/blood-2005-08-3443

[32]

10.1038/modpathol.2013.156

[33]

10.1001/archdermatol.2009.23

[34]

10.1001/archdermatol.2009.345

[35]

Wobser M "Primary cutaneous diffuse large B‐cell lymphoma, leg‐type, treated with a modified R‐CHOP immunochemotherapy – diagnostic and therapeutic challenges" J Dtsch Dermatol Ges (2011) 10.1111/j.1610-0387.2010.07578.x

[36]

10.1016/j.ijrobp.2013.07.019

[37]

10.1007/s00105-013-2736-5

[38]

10.1111/ejh.12315

[39]

10.1007/s00277-013-1787-0

[40]

10.1159/000294963

[41]

10.1200/jco.2012.46.5203

[42]

10.1016/j.jaad.2015.02.1134

[43]

10.1200/jco.2015.65.9789

[44]

10.4081/rt.2015.6067

[45]

10.1111/j.1365-2133.2012.11122.x

Metrics

15

Citations

45

References

Details

Published: Dec 01, 2016
Vol/Issue: 14(12)
Pages: 1207-1224
License: View

Authors

J

Jan P. Nicolay

Department of Dermatology Venereology and Allergy University Medical Center Mannheim Ruprecht‐Karls‐University of Heidelberg Mannheim Germany

M

Marion Wobser

Department of Dermatology Venereology and Allergology University Hospital Würzburg Germany

Cite This Article

Jan P. Nicolay, Marion Wobser (2016). Cutaneous B‐cell lymphomas – pathogenesis, diagnostic workup, and therapy. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 14(12), 1207-1224. https://doi.org/10.1111/ddg.13164

Cutaneous B‐cell lymphomas – pathogenesis, diagnostic workup, and therapy

You May Also Like