High prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies

Y. Kouidrat; D. Pizzol; T. Cosco; T. Thompson; M. Carnaghi; A. Bertoldo; M. Solmi; B. Stubbs; N. Veronese

doi:10.1111/dme.13403

journal article Jul 18, 2017

High prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies

Y. Kouidrat D. Pizzol

T. Cosco T. Thompson M. Carnaghi A. Bertoldo M. Solmi B. Stubbs N. Veronese

Diabetic Medicine Vol. 34 No. 9 pp. 1185-1192 · Wiley

View at Publisher Save 10.1111/dme.13403

Abstract

AbstractErectile dysfunction may be common among men with diabetes, but its prevalence is still debated. We aimed to assess the relative prevalence of erectile dysfunction in diabetes searching major databases from inception to November 2016 for studies reporting erectile dysfunction in men with Type 1 and Type 2 diabetes mellitus. We conducted a meta‐analysis of the prevalence [and 95% confidence intervals (95% CIs)] of erectile dysfunction in diabetes compared with healthy controls, calculating the relative odds ratios (ORs) and 95% CIs. A random effect model was applied. From 3747 initial hits, 145 studies were included representing 88 577 men (age: 55.8 ± 7.9 years). The prevalence of erectile dysfunction in diabetes overall was 52.5% (95% CI, 48.8 to 56.2) after adjusting for publication bias, and 37.5%, 66.3% and 57.7% in Type 1, Type 2 and both types of diabetes, respectively (P for interaction < 0.0001). The prevalence of erectile dysfunction was highest in studies using the Sexual Health Inventory for Men (82.2%, 17 studies, P for interaction < 0.0001). Studies with a higher percentage of people with hypertension moderated our results (beta = 0.03; 95% CI, 0.008 to 0.040; P = 0.003; R2 = 0.00). Compared to healthy controls (n = 5385) men with diabetes (n = 863) were at increased odds of having erectile dysfunction (OR 3.62; 95% CI, 2.53 to 5.16; P < 0.0001; I2 = 67%, k = 8). Erectile dysfunction is common in diabetes, affecting more than half of men with the condition and with a prevalence odds of approximately 3.5 times more than controls. Our findings suggest that screening and appropriate intervention for men with erectile dysfunction is warranted.

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References

Details

Published: Jul 18, 2017
Vol/Issue: 34(9)
Pages: 1185-1192
License: View

Authors

Y

Y. Kouidrat

Department of Nutrition Maritime Hospital of Berck France; Department of Psychosis Studies Institute of Psychiatry, King's College London UK

D

D. Pizzol

Operational Research Unit Doctors with Africa Cuamm Beira Mozambique

T

T. Cosco

MRC Unit for Lifelong Health and Ageing at UCL London UK; Oxford Institute of Population Ageing, University of Oxford London UK

T

T. Thompson

Faculty of Education and Health University of Greenwich London UK

M

M. Carnaghi

Operational Research Unit Doctors with Africa Cuamm Beira Mozambique

A

A. Bertoldo

Zerouno Procreazione, Centro di Medicina, Venezia Mestre Padova Italy

M

M. Solmi

Department of Neurosciences University of Padova Padova Italy; Institute of Clinical Research and Education in Medicine (IREM) Padova Italy

B

B. Stubbs

Health Service and Population Research Department Institute of Psychiatry, Psychology and Neuroscience, King's College London; Faculty of Health, Social Care and Education Anglia Ruskin University Chelmsford; Physiotherapy Department South London and Maudsley NHS Foundation Trust London UK

N

N. Veronese

Institute of Clinical Research and Education in Medicine (IREM) Padova Italy; National Research Council Neuroscience Institute, Aging Branch Padova Italy

Cite This Article

Y. Kouidrat, D. Pizzol, T. Cosco, et al. (2017). High prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies. Diabetic Medicine, 34(9), 1185-1192. https://doi.org/10.1111/dme.13403

High prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies

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