Molecular components of the circadian clock in mammals

J. S. Takahashi

doi:10.1111/dom.12514

journal article Sep 01, 2015

Molecular components of the circadian clock in mammals

J. S. Takahashi

Diabetes, Obesity and Metabolism Vol. 17 No. S1 pp. 6-11 · Wiley

View at Publisher Save 10.1111/dom.12514

Abstract

Abstract

The circadian clock mechanism in animals involves a transcriptional feedback loop in which the
bHLH‐PAS
proteins
CLOCK
and
BMAL1
form a transcriptional activator complex to activate the transcription of the
Period
and
Cryptochrome
genes, which in turn feed back to repress their own transcription. In the mouse liver,
CLOCK
and
BMAL1
interact with the regulatory regions of thousands of genes, which are both cyclically and constitutively expressed. The circadian transcription in the liver is clustered in phase and this is accompanied by circadian occupancy of
RNA
polymerase
II
recruitment and initiation. These changes also lead to circadian fluctuations in histone
H3
lysine4 trimethylation (
H3K4me3
) as well as
H3
lysine9 acetylation (
H3K9ac
) and
H3
lysine27 acetylation (
H3K27ac
). Thus, the circadian clock regulates global transcriptional poise and chromatin state by regulation of
RNA
polymerase
II
.

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Metrics

192

Citations

40

References

Details

Published: Sep 01, 2015
Vol/Issue: 17(S1)
Pages: 6-11
License: View

Authors

J

J. S. Takahashi

Howard Hughes Medical Institute University of Texas Southwestern Medical Center Dallas TX USA; Department of Neuroscience University of Texas Southwestern Medical Center Dallas TX USA

Cite This Article

J. S. Takahashi (2015). Molecular components of the circadian clock in mammals. Diabetes, Obesity and Metabolism, 17(S1), 6-11. https://doi.org/10.1111/dom.12514

Molecular components of the circadian clock in mammals

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