Comparative effects of liraglutide 3 mg vs structured lifestyle modification on body weight, liver fat and liver function in obese patients with non‐alcoholic fatty liver disease: A pilot randomized trial
NAFLD
). Obese (body mass index ≥30 kg/m
2
, mean weight 96.0 ± 16.3 kg) non‐diabetic Asian adults, with
NAFLD
diagnosed by liver fat fraction (
LFF
) ≥ 5.5% on magnetic resonance imaging without other causes of hepatic steatosis, were randomized to a supervised program of dieting (restriction by 400 kilocalories/d) plus moderate‐intensity aerobic exercise (~200 min/wk;
DE
group,
n
= 12), or liraglutide at the 3 mg daily dose approved for weight loss (
LI
group,
n
= 12), for 26 weeks. Both
DE
and
LI
groups had significant (
P
< .01) and similar reductions in weight (−3.5 ± 3.3 vs −3.5 ± 2.1 kg, respectively,
P
= .72),
LFF
(−8.9 ± 13.4 vs −7.2% ± 7.1%,
P
= .70), serum alanine aminotransferase (−42 ± 46 vs −34 ± 27 U/L,
P
= .52) and aspartate aminotransferase (−23 ± 24 vs −18 ± 15 U/L,
P
= .53). In this first randomized study comparing the 2 weight‐loss modalities for improving
NAFLD
, liraglutide was as effective as structured lifestyle modification.
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- Published
- Jul 14, 2017
- Vol/Issue
- 19(12)
- Pages
- 1814-1817
- License
- View
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