Signals in the pancreatic islet microenvironment influence β‐cell proliferation

Kristie I. Aamodt; Alvin C. Powers

doi:10.1111/dom.13031

journal article Sep 01, 2017

Signals in the pancreatic islet microenvironment influence β‐cell proliferation

Kristie I. Aamodt Alvin C. Powers

Diabetes, Obesity and Metabolism Vol. 19 No. S1 pp. 124-136 · Wiley

View at Publisher Save 10.1111/dom.13031

Abstract

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2 diabetes is a primary factor driving efforts to identify strategies for effectively increasing, enhancing or restoring β‐cell mass. While factors that seem to influence β‐cell proliferation in specific contexts have been described, reliable stimulation of human β‐cell proliferation has remained a challenge. Importantly, β‐cells exist in the context of a complex, integrated pancreatic islet microenvironment where they interact with other endocrine cells, vascular endothelial cells, extracellular matrix, neuronal projections and islet macrophages. This review highlights different components of the pancreatic microenvironment, and reviews what is known about how signaling that occurs between β‐cells and these other components influences β‐cell proliferation. Future efforts to further define the role of the pancreatic islet microenvironment on β‐cell proliferation may lead to the development of successful approaches to increase or restore β‐cell mass in diabetes.

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Details

Published: Sep 01, 2017
Vol/Issue: 19(S1)
Pages: 124-136
License: View

Authors

K

Kristie I. Aamodt

Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine Nashville TN

A

Alvin C. Powers

Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine Nashville TN; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Vanderbilt University Medical Center Nashville TN; VA Tennessee Valley Healthcare System Nashville TN

Funding

National Institute of General Medical Sciences Award: T32 GM007347

National Institute of Diabetes and Digestive and Kidney Diseases Award: DK72473

Cite This Article

Kristie I. Aamodt, Alvin C. Powers (2017). Signals in the pancreatic islet microenvironment influence β‐cell proliferation. Diabetes, Obesity and Metabolism, 19(S1), 124-136. https://doi.org/10.1111/dom.13031

Signals in the pancreatic islet microenvironment influence β‐cell proliferation

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