Effects of acute fructose loading on levels of serum uric acid—a pilot study

Camilla Olofsson; Björn Anderstam; Ann‐Christin Bragfors‐Helin; Monica Eriksson; Abdul R. Qureshi; Bengt Lindholm; Agneta Hilding; Wieslaw Wiczkowski; Nicola Orsini; Peter Stenvinkel; Neda Rajamand Ekberg

doi:10.1111/eci.13040

journal article Nov 16, 2018

Effects of acute fructose loading on levels of serum uric acid—a pilot study

Camilla Olofsson

Björn Anderstam Ann‐Christin Bragfors‐Helin Monica Eriksson Abdul R. Qureshi Bengt Lindholm

Agneta Hilding Wieslaw Wiczkowski Nicola Orsini Peter Stenvinkel

Neda Rajamand Ekberg

European Journal of Clinical Investigation Vol. 49 No. 1 · Wiley

View at Publisher Save 10.1111/eci.13040

Abstract

AbstractBackgroundFructose intake may lead to hyperuricaemia, which is associated with increased risk and progression of kidney disease. We aimed to explore the acute effects of fructose loading from different sources, with and without a pizza, on levels of serum uric acid in patients with chronic kidney disease (CKD), type 2 diabetes (T2D) without CKD, and in healthy subjects (HS).MethodsThe study included six HS, and three CKD stage 4‐5 and seven T2D patients. Drinks consumed were blueberry drink (17.5 g fructose), Coca‐Cola (18 g fructose) and fructose drink (35 g fructose). The drinks were also combined with pizza, in total six interventions. Serum samples were collected fasting and 30, 60, 90 and 120 minutes after intake and also 240 minutes after drink + pizza, and analysed for fructose, uric acid and triglycerides. Postprandial responses were explored using repeated‐measure ANOVA.ResultsBaseline serum uric acid levels were increased in CKD (P = 0.037). There were significant differences in serum fructose and serum uric levels over time between drinks and drinks + pizza for all groups (P < 0.001 and P < 0.05, respectively). The highest peak in serum fructose followed the fructose drink interventions and the lowest the blueberry drink. The fructose drink interventions gave the highest responses in serum uric acid and the lowest responses followed the blueberry drink. Triglycerides increased following pizza interventions (P < 0.001).ConclusionsIntake of fructose increases serum uric acid. The fructose intake via a blueberry drink induced lowest increase and thus may be protective.

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12

Citations

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References

Details

Published: Nov 16, 2018
Vol/Issue: 49(1)
License: View

Authors

C

Camilla Olofsson

Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden

B

Björn Anderstam

Division of Renal Medicine M99 CLINTEC, Karolinska Institutet Stockholm Sweden

A

Ann‐Christin Bragfors‐Helin

Division of Renal Medicine M99 CLINTEC, Karolinska Institutet Stockholm Sweden

M

Monica Eriksson

Division of Renal Medicine M99 CLINTEC, Karolinska Institutet Stockholm Sweden

A

Abdul R. Qureshi

Division of Renal Medicine M99 CLINTEC, Karolinska Institutet Stockholm Sweden

B

Bengt Lindholm

Division of Renal Medicine M99 CLINTEC, Karolinska Institutet Stockholm Sweden

A

Agneta Hilding

Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden

W

Wieslaw Wiczkowski

Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences Olsztyn Poland

N

Nicola Orsini

Department of Public Health Sciences Karolinska Institutet Stockholm Sweden

P

Peter Stenvinkel

Division of Renal Medicine M99 CLINTEC, Karolinska Institutet Stockholm Sweden

N

Neda Rajamand Ekberg

Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden

Funding

Vetenskapsrådet

Cite This Article

Camilla Olofsson, Björn Anderstam, Ann‐Christin Bragfors‐Helin, et al. (2018). Effects of acute fructose loading on levels of serum uric acid—a pilot study. European Journal of Clinical Investigation, 49(1). https://doi.org/10.1111/eci.13040

Effects of acute fructose loading on levels of serum uric acid—a pilot study

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