Current development of chimeric antigen receptor T‐cell therapy for diffuse large B‐cell lymphoma and high‐grade B‐cell lymphoma
Chimeric antigen receptor (CAR) T‐cell therapy has become a commercially available treatment option for relapsed or refractory (r/r) diffuse large B‐cell lymphoma (DLBCL) with two or more lines of prior therapies, and recently for high‐risk r/r DLBCL with one prior line of therapy. The successful development of CAR T‐cell therapy for multiple relapsed DLBCL has led to a boom in subsequent trials that investigated its utility in patients with other r/r B‐cell lymphoma subtypes. However, CAR T‐cell therapy is a multistep process that includes leukapheresis and manipulation which take several weeks. Therefore, patients with rapidly progressing or bulky disease may not be able to complete the therapeutic regimen involving CAR T‐cell products. This raises the question of the generalizability of the results of pivotal studies to the entire population. In this review, we summarize the development of CAR‐T cell therapy for B‐cell lymphoma and discuss strategies to further improve the clinical outcomes of this treatment.
No keywords indexed for this article. Browse by subject →
Sattva S. Neelapu, Frederick L. Locke, Nancy L. Bartlett et al.
Stephen J. Schuster, Michael R. Bishop, Constantine S. Tam et al.
Michael Crump, Sattva S. Neelapu, Umar Farooq et al.
Stephen J Schuster, Constantine S Tam, Peter Borchmann et al.
Caron A. Jacobson, Frederick L. Locke, Long Ma et al.
Emmanuel Bachy, Steven Le Gouill, Roberta Di Blasi et al.
Frederick L. Locke, David B. Miklos, Caron A. Jacobson et al.
Michael J. Dickinson, Carmelo Carlo-Stella, Franck Morschhauser et al.
Catherine Thieblemont, Tycel Phillips, Herve Ghesquieres et al.
Jordan Gauthier, Evandro D. Bezerra, Alexandre V. Hirayama et al.
- Published
- Jan 03, 2024
- Vol/Issue
- 112(5)
- Pages
- 662-677
- License
- View
You May Also Like
Antonis Kattamis, Gian Luca Forni · 2020
272 citations
Odile Moulard, Jyotsna Mehta · 2014
205 citations
M. M. Brandão, A. Fontes · 2003
197 citations
Christina Ramsenthaler, Pauline Kane · 2016
135 citations