Insights into the processes that drive the evolution of drug resistance in Mycobacterium tuberculosis

Quang Huy Nguyen; Lucie Contamin; Thi Van Anh Nguyen; Anne‐Laure Bañuls

doi:10.1111/eva.12654

journal article Open Access Jun 21, 2018

Insights into the processes that drive the evolution of drug resistance in Mycobacterium tuberculosis

Quang Huy Nguyen

Lucie Contamin Thi Van Anh Nguyen

Anne‐Laure Bañuls

Evolutionary Applications Vol. 11 No. 9 pp. 1498-1511 · Wiley

View at Publisher Save 10.1111/eva.12654

Abstract

AbstractAt present, the successful transmission of drug‐resistant Mycobacterium tuberculosis, including multidrug‐resistant (MDR) and extensively drug‐resistant (XDR) strains, in human populations, threatens tuberculosis control worldwide. Differently from many other bacteria, M. tuberculosis drug resistance is acquired mainly through mutations in specific drug resistance‐associated genes. The panel of mutations is highly diverse, but depends on the affected gene and M. tuberculosis genetic background. The variety of genetic profiles observed in drug‐resistant clinical isolates underlines different evolutionary trajectories towards multiple drug resistance, although some mutation patterns are prominent. This review discusses the intrinsic processes that may influence drug resistance evolution in M. tuberculosis, such as mutation rate, drug resistance‐associated mutations, fitness cost, compensatory mutations and epistasis. This knowledge should help to better predict the risk of emergence of highly resistant M. tuberculosis strains and to develop new tools and strategies to limit the development and spread of MDR and XDR strains.

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Details

Published: Jun 21, 2018
Vol/Issue: 11(9)
Pages: 1498-1511
License: View

Authors

Q

Quang Huy Nguyen

Department of Pharmacological, Medical and Agronomical Biotechnology University of Science and Technology of Hanoi Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam; Institute of Research for Development UMR MIVEGEC (CNRS‐IRD‐University of Montpellier) Montpellier France; LMI Drug Resistance in South East Asia (LMI DRISA) University of Science and Technology of Hanoi Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam

L

Lucie Contamin

Institute of Research for Development UMR MIVEGEC (CNRS‐IRD‐University of Montpellier) Montpellier France; LMI Drug Resistance in South East Asia (LMI DRISA) University of Science and Technology of Hanoi Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam; Department of Bacteriology National Institute of Hygiene and Epidemiology (NIHE) Hanoi Vietnam

T

Thi Van Anh Nguyen

Department of Bacteriology National Institute of Hygiene and Epidemiology (NIHE) Hanoi Vietnam

A

Anne‐Laure Bañuls

Institute of Research for Development UMR MIVEGEC (CNRS‐IRD‐University of Montpellier) Montpellier France; LMI Drug Resistance in South East Asia (LMI DRISA) University of Science and Technology of Hanoi Vietnam Academy of Science and Technology (VAST) Hanoi Vietnam; Department of Bacteriology National Institute of Hygiene and Epidemiology (NIHE) Hanoi Vietnam

Funding

Ministry of Science and Technology

Cite This Article

Quang Huy Nguyen, Lucie Contamin, Thi Van Anh Nguyen, et al. (2018). Insights into the processes that drive the evolution of drug resistance in Mycobacterium tuberculosis. Evolutionary Applications, 11(9), 1498-1511. https://doi.org/10.1111/eva.12654

Insights into the processes that drive the evolution of drug resistance in Mycobacterium tuberculosis

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