Insulin‐like growth factor‐1: roles in androgenetic alopecia

Ratchathorn Panchaprateep; Pravit Asawanonda

doi:10.1111/exd.12339

journal article Mar 01, 2014

Insulin‐like growth factor‐1: roles in androgenetic alopecia

Ratchathorn Panchaprateep Pravit Asawanonda

Experimental Dermatology Vol. 23 No. 3 pp. 216-218 · Wiley

View at Publisher Save 10.1111/exd.12339

Abstract

AbstractOf all the cytokines or growth factors that have been postulated to play a role in hair follicle, insulin‐like growth factor‐1 (IGF‐1) is known to be regulated by androgens. However, how IGF‐1 is altered in the balding scalp has not yet been investigated. In this study, expressions of IGF‐1 and its binding proteins by dermal papilla (DP) cells obtained from balding versus non‐balding hair follicles were quantified using growth factor array. DP cells from balding scalp follicles were found to secrete significantly less IGF‐1, IGFBP‐2 and IGFBP‐4 (P < 0.05) than their non‐balding counterparts. Our data confirmed that the downregulation of IGF‐1 may be one of the important mechanisms contributing to male pattern baldness.

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References

14

[1]

10.1111/j.0022-202x.2005.23946.x

[2]

10.1111/1523-1747.ep12382494

[3]

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Jeh-Ping Liu, Julie Baker, Archlbald S. Perkins et al.

Cell 10.1016/s0092-8674(05)80084-4

[4]

10.1006/bbrc.1995.2067

[5]

10.1111/j.1365-2133.2011.10514.x

[6]

10.1111/1523-1747.ep12340934

[7]

10.1096/fasebj.14.5.629

[8]

Harris P J Cancer Prev Res (Phila) (2010) 10.1158/1940-6207.capr-10-0210

[9]

10.1067/s0190-9622(03)00777-1

[10]

10.1111/j.1365-2133.2009.09108.x

[11]

10.1111/j.0906-6705.2004.00203.x

[12]

10.1111/j.1365-2230.2012.04441.x

[13]

10.1046/j.1087-0024.2003.00807.x

[14]

10.1016/s0002-9440(10)63151-3

Metrics

43

Citations

14

References

Details

Published: Mar 01, 2014
Vol/Issue: 23(3)
Pages: 216-218
License: View

Authors

R

Ratchathorn Panchaprateep

Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand

P

Pravit Asawanonda

Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand

Funding

Chulalongkorn University Award: RA 22/52

Thai Government Award: GRB_BSS_22_53_30_11

Cite This Article

Ratchathorn Panchaprateep, Pravit Asawanonda (2014). Insulin‐like growth factor‐1: roles in androgenetic alopecia. Experimental Dermatology, 23(3), 216-218. https://doi.org/10.1111/exd.12339

Insulin‐like growth factor‐1: roles in androgenetic alopecia

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