Programmed necrosis and necroptosis signalling

Maria Feoktistova; Martin Leverkus

doi:10.1111/febs.13120

journal article Nov 11, 2014

Programmed necrosis and necroptosis signalling

Maria Feoktistova Martin Leverkus

The FEBS Journal Vol. 282 No. 1 pp. 19-31 · Wiley

View at Publisher Save 10.1111/febs.13120

Abstract

In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor‐interacting serine/threonine protein kinase1 (RIPK1), RIPK3, and mixed‐lineage kinase domain‐like protein, and the molecular signalling platforms in which these molecules participate, are being intensively studied. In particular, the role of RIPK1, being both a kinase and a scaffold molecule, in different cell death regulatory complexes is of great relevance for the field. This minireview aims to introduce the emerging and dynamic field of necroptosis to the reader, with a specific focus on intracellular signalling pathways involved in this process.

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Metrics

130

Citations

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References

Details

Published: Nov 11, 2014
Vol/Issue: 282(1)
Pages: 19-31
License: View

Authors

M

Maria Feoktistova

Section of Molecular Dermatology Department of Dermatology, Venereology and Allergology Medical Faculty Mannheim University Heidelberg Germany

M

Martin Leverkus

Section of Molecular Dermatology Department of Dermatology, Venereology and Allergology Medical Faculty Mannheim University Heidelberg Germany

Funding

Deutsche Forschungsgemeinschaft Award: 953/6-1 and 953/8-1

Cite This Article

Maria Feoktistova, Martin Leverkus (2014). Programmed necrosis and necroptosis signalling. The FEBS Journal, 282(1), 19-31. https://doi.org/10.1111/febs.13120

Programmed necrosis and necroptosis signalling

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