Translation initiation and its relevance in colorectal cancer

Emma Minnee; William James Faller

doi:10.1111/febs.15690

journal article Open Access Jan 24, 2021

Translation initiation and its relevance in colorectal cancer

Emma Minnee William James Faller

The FEBS Journal Vol. 288 No. 23 pp. 6635-6651 · Wiley

View at Publisher Save 10.1111/febs.15690

Abstract

Protein synthesis is one of the most essential processes in every kingdom of life, and its dysregulation is a known driving force in cancer development. Multiple signaling pathways converge on the translation initiation machinery, and this plays a crucial role in regulating differential gene expression. In colorectal cancer, dysregulation of initiation results in translational reprogramming, which promotes the selective translation of mRNAs required for many oncogenic processes. The majority of upstream mutations found in colorectal cancer, including alterations in the WNT, MAPK, and PI3K\AKT pathways, have been demonstrated to play a significant role in translational reprogramming. Many translation initiation factors are also known to be dysregulated, resulting in translational reprogramming during tumor initiation and/or maintenance. In this review, we outline the role of translational reprogramming that occurs during colorectal cancer development and progression and highlight some of the most critical factors affecting the etiology of this disease.

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Details

Published: Jan 24, 2021
Vol/Issue: 288(23)
Pages: 6635-6651
License: View

Authors

E

Emma Minnee

Division of Oncogenomics Netherlands Cancer Institute Amsterdam The Netherlands

W

William James Faller

Division of Oncogenomics Netherlands Cancer Institute Amsterdam The Netherlands

Cite This Article

Emma Minnee, William James Faller (2021). Translation initiation and its relevance in colorectal cancer. The FEBS Journal, 288(23), 6635-6651. https://doi.org/10.1111/febs.15690

Translation initiation and its relevance in colorectal cancer

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