Complement cascade functions during brain development and neurodegeneration

Oluwaseun Fatoba; Takahide Itokazu; Toshihide Yamashita

doi:10.1111/febs.15772

journal article Mar 01, 2021

Complement cascade functions during brain development and neurodegeneration

Oluwaseun Fatoba Takahide Itokazu Toshihide Yamashita

The FEBS Journal Vol. 289 No. 8 pp. 2085-2109 · Wiley

View at Publisher Save 10.1111/febs.15772

Abstract

The complement system, an essential tightly regulated innate immune system, is a key regulator of normal central nervous system (CNS) development and function. However, aberrant complement component expression and activation in the brain may culminate into marked neuroinflammatory response, neurodegenerative processes and cognitive impairment. Over the years, complement‐mediated neuroinflammatory responses and complement‐driven neurodegeneration have been increasingly implicated in the pathogenesis of a wide spectrum of CNS disorders. This review describes how complement system contributes to normal brain development and function. We also discuss how pathologic insults such as misfolded proteins, lipid droplet/lipid droplet‐associated protein or glycosaminoglycan accumulation could trigger complement‐mediated neuroinflammatory responses and neurodegenerative process in neurodegenerative proteinopathies, age‐related macular degeneration and neurodegenerative lysosomal storage disorders.

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Details

Published: Mar 01, 2021
Vol/Issue: 289(8)
Pages: 2085-2109
License: View

Authors

O

Oluwaseun Fatoba

Department of Molecular Neuroscience Graduate School of Medicine Osaka University Suita Japan; WPI‐Immunology Frontier Research Center Osaka University Suita Japan

T

Takahide Itokazu

Department of Molecular Neuroscience Graduate School of Medicine Osaka University Suita Japan; Department of Neuro‐Medical Science Graduate School of Medicine Osaka University Suita Japan

T

Toshihide Yamashita

Department of Molecular Neuroscience Graduate School of Medicine Osaka University Suita Japan; WPI‐Immunology Frontier Research Center Osaka University Suita Japan; Department of Neuro‐Medical Science Graduate School of Medicine Osaka University Suita Japan

Cite This Article

Oluwaseun Fatoba, Takahide Itokazu, Toshihide Yamashita (2021). Complement cascade functions during brain development and neurodegeneration. The FEBS Journal, 289(8), 2085-2109. https://doi.org/10.1111/febs.15772

Complement cascade functions during brain development and neurodegeneration

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