Potential roles of super enhancers in inflammatory gene transcription

Yoshiki Higashijima; Yasuharu Kanki

doi:10.1111/febs.16089

journal article Jul 10, 2021

Potential roles of super enhancers in inflammatory gene transcription

Yoshiki Higashijima

Yasuharu Kanki

The FEBS Journal Vol. 289 No. 19 pp. 5762-5775 · Wiley

View at Publisher Save 10.1111/febs.16089

Abstract

Acute and chronic inflammation is a basic pathological event that contributes to atherosclerosis, cancer, infectious diseases, and immune disorders. Inflammation is an adaptive process to both external and internal stimuli experienced by the human body. Although the mechanism of gene transcription is highly complicated and orchestrated in a timely and spatial manner, recent developments in next‐generation sequencing, genome‐editing, cryo‐electron microscopy, and single cell‐based technologies could provide us with insights into the roles of super enhancers (SEs). Initially, SEs were implicated in determining cell fate; subsequent studies have clarified that SEs are associated with various pathological conditions, including cancer and inflammatory diseases. Recent technological advances have unveiled the molecular mechanisms of SEs, which involve epigenetic histone modifications, chromatin three‐dimensional structures, and phase‐separated condensates. In this review, we discuss the relationship between inflammation and SEs and the therapeutic potential of SEs for inflammatory diseases.

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References

Details

Published: Jul 10, 2021
Vol/Issue: 289(19)
Pages: 5762-5775
License: View

Authors

Y

Yoshiki Higashijima

Department of Proteomics The Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences University of Copenhagen Denmark

Y

Yasuharu Kanki

Isotope Science Center The University of Tokyo Japan; Laboratory of Laboratory/Sports Medicine Division of Clinical Medicine Faculty of Medicine University of Tsukuba Japan

Funding

Japan Society for the Promotion of Science Award: 16K15438

Takeda Science Foundation

Uehara Memorial Foundation

SENSHIN Medical Research Foundation

Japan Foundation for Applied Enzymology

Cite This Article

Yoshiki Higashijima, Yasuharu Kanki (2021). Potential roles of super enhancers in inflammatory gene transcription. The FEBS Journal, 289(19), 5762-5775. https://doi.org/10.1111/febs.16089

Potential roles of super enhancers in inflammatory gene transcription

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