Patients’ and parents’ satisfaction with, and preference for, haemophilia A treatments: a cross‐sectional, multicentre, observational study

Young Shil Park; Tai Ju Hwang; Goon Jae Cho; Soon Ki Kim; Sang Kyu Park; Ji Yoon Kim; Hee Jo Baek; Ho‐Jin Lee; Ji‐Soo Shin; Chung‐Mo Nam; Jiyu Sun; Ki Young Yoo

doi:10.1111/hae.14304

journal article Open Access Jun 15, 2021

Patients’ and parents’ satisfaction with, and preference for, haemophilia A treatments: a cross‐sectional, multicentre, observational study

Young Shil Park

Tai Ju Hwang Goon Jae Cho Soon Ki Kim

Sang Kyu Park

Ji Yoon Kim

Hee Jo Baek

Ho‐Jin Lee Ji‐Soo Shin Chung‐Mo Nam

Jiyu Sun Ki Young Yoo

Haemophilia Vol. 27 No. 4 pp. 563-573 · Wiley

View at Publisher Save 10.1111/hae.14304

Abstract

ABSTRACTIntroductionReports on patients’ satisfaction and preferred characteristics for treatments would be worthwhile when choosing an optimal treatment reflecting patients’ perspectives.AimTo identify the characteristics and treatment patterns of patients with haemophilia A, or their caregivers, in Korea and explore patient preferences and satisfaction with their treatment.MethodsThis cross‐sectional, multicentre, observational study was conducted from April 2018 to September 2019 at six nationwide hospitals and three Korea Hemophilia Foundation clinics. Patients aged ≥16 years, or legal caregivers of paediatric patients, who had used factor VIII (FVIII) concentrates for ≥1 month were enrolled. Satisfaction with treatment was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM); preference was evaluated using discrete choice experiment (DCE), with 10 series of two hypothetical treatment options created from D‐efficient block design, which varied across five attributes.ResultsOverall, 505 patients (mean age 31 years) were enrolled in the study. Patients had received FVIII concentrate for an average of 102.9 months (prophylaxis: 53.5%; on‐demand: 22.2%). Mean TSQM scores were 64.6 (effectiveness domain), 97.9 (side effects), 57.1 (convenience) and 66.8 (global satisfaction). The number of vials per injection, and the frequency of drug administration, was significantly associated with treatment satisfaction. According to DCE, simpler treatment options were preferred by patients/caregivers.ConclusionThe lowest satisfaction levels were shown in the treatment convenience domain. Patients/parents preferred simpler and easier treatment characteristics. In an attempt to enhance the overall satisfaction of patients and caregivers with treatment, consideration of more convenient characteristics is required in future decisions regarding treatment selection.

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Details

Published: Jun 15, 2021
Vol/Issue: 27(4)
Pages: 563-573
License: View

Authors

Y

Young Shil Park

Department of Pediatrics Kyung Hee University Hospital at Gangdong Seoul South Korea

T

Tai Ju Hwang

Korea Hemophilia Foundation Gwangju Clinic Gwang‐Ju South Korea

G

Goon Jae Cho

Korea Hemophilia Foundation Busan Clinic Busan South Korea

S

Soon Ki Kim

Department of Pediatrics Inha University Hospital Incheon South Korea

S

Sang Kyu Park

Department of Pediatrics Ulsan University Hospital Ulsan South Korea

J

Ji Yoon Kim

Department of Pediatrics Kyungpook National University Hospital Daegu South Korea; Department of Pediatric Hematology and Oncology Kyungpook National University Chilgok Hospital Daegu South Korea

H

Hee Jo Baek

Department of Pediatrics Chonnam National University Hwasun Hospital Chonnam National University Medical School Gwangju South Korea

H

Ho‐Jin Lee

Medical Department Pfizer Pharmaceuticals Korea Ltd Seoul South Korea

J

Ji‐Soo Shin

Medical Department Pfizer Pharmaceuticals Korea Ltd Seoul South Korea

C

Chung‐Mo Nam

Department of Biostatistics and Computing Yonsei University Seoul South Korea

J

Jiyu Sun

Department of Biostatistics and Computing Yonsei University Seoul South Korea

K

Ki Young Yoo

Korea Hemophilia Foundation Clinic (KHF Clinic Seoul South Korea

Cite This Article

Young Shil Park, Tai Ju Hwang, Goon Jae Cho, et al. (2021). Patients’ and parents’ satisfaction with, and preference for, haemophilia A treatments: a cross‐sectional, multicentre, observational study. Haemophilia, 27(4), 563-573. https://doi.org/10.1111/hae.14304

Patients’ and parents’ satisfaction with, and preference for, haemophilia A treatments: a cross‐sectional, multicentre, observational study

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