Protein kinase C in the immune system: from signalling to chromatin regulation

Pek Siew Lim; Christopher Ray Sutton; Sudha Rao

doi:10.1111/imm.12510

journal article Oct 06, 2015

Protein kinase C in the immune system: from signalling to chromatin regulation

Pek Siew Lim Christopher Ray Sutton Sudha Rao

Immunology Vol. 146 No. 4 pp. 508-522 · Wiley

View at Publisher Save 10.1111/imm.12510

Abstract

SummaryProtein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune system, PKCs are involved in regulating signal transduction pathways important for both innate and adaptive immunity, ultimately resulting in the expression of key immune genes. PKCs act as mediators during immune cell signalling through the immunological synapse. PKCs are traditionally known to be cytoplasmic signal transducers and are well embedded in the signalling pathways of cells to mediate the cells' response to a stimulus from the plasma membrane to the nucleus. PKCs are also found to transduce signals within the nucleus, a process that is distinct from the cytoplasmic signalling pathway. There is now growing evidence suggesting that PKC can directly regulate gene expression programmes through a non‐traditional role as nuclear kinases. In this review, we will focus on the role of PKCs as key cytoplasmic signal transducers in immune cell signalling, as well as its role in nuclear signal transduction. We will also highlight recent evidence for its newly discovered regulatory role in the nucleus as a chromatin‐associated kinase.

Topics

No keywords indexed for this article. Browse by subject →

References

154

[1]

10.1016/s0167-4889(97)00080-3

[2]

10.1021/cr0002801

[3]

10.1002/pro.5560051201

[4]

10.1074/jbc.m510251200

[5]

10.1073/pnas.94.12.6191

[6]

10.1074/jbc.270.48.28495

[7]

10.4061/2011/537821

[8]

10.1146/annurev.immunol.20.100301.064807

[9]

10.1016/j.drudis.2014.05.008

[10]

10.1146/annurev.biochem.76.060605.122847

[11]

10.1146/annurev.cellbio.21.122303.115827

[12]

10.1016/j.tim.2004.02.009

[13]

10.1038/ni986

[14]

10.1146/annurev.biochem.76.060305.151318

[15]

10.1146/annurev-biochem-052909-141507

[16]

Protein Kinase Cϵ Is Required for Macrophage Activation and Defense Against Bacterial Infection

Antonio Castrillo, Daniel J. Pennington, Florian Otto et al.

The Journal of Experimental Medicine 10.1084/jem.194.9.1231

[17]

10.1074/jbc.m710330200

[18]

10.1073/pnas.0600462103

[19]

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

Katherine A. Fitzgerald, Daniel C. Rowe, Betsy J. Barnes et al.

The Journal of Experimental Medicine 10.1084/jem.20031023

[20]

10.1038/41131

[21]

10.1016/j.immuni.2011.05.006

[22]

10.1038/ni712

[23]

10.1146/annurev.immunol.18.1.165

[24]

10.1073/pnas.092284399

[25]

10.1016/s0006-2952(98)00213-5

[26]

10.1146/annurev.immunol.021908.132706

[27]

10.1146/annurev-immunol-030409-101308

[28]

10.1007/978-3-642-03858-7_5

[29]

10.1016/j.it.2013.01.002

[30]

10.1038/385083a0

[31]

10.1016/s0021-9258(18)53494-3

[32]

10.1038/25764

[33]

10.1073/pnas.142298399

[34]

10.1038/ni.2120

[35]

10.1016/j.immuni.2008.08.011

[36]

10.1002/eji.201243140

[37]

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

Zuoming Sun, Christopher W. Arendt, Wilfried Ellmeier et al.

Nature 10.1038/35006090

[38]

10.1080/08916930600907954

[39]

10.1084/jem.20020234

[40]

10.1084/jem.20032229

[41]

10.4049/jimmunol.175.11.7635

[42]

10.4049/jimmunol.176.5.2872

[43]

10.4049/jimmunol.1102941

[44]

10.1371/journal.pone.0096401

[45]

10.1073/pnas.0506250102

[46]

10.1016/j.it.2008.01.005

[47]

10.1126/science.1163612

[48]

10.1016/j.molimm.2008.08.275

[49]

10.1126/science.1186068

[50]

10.4049/jimmunol.1102979

Showing 50 of 154 references

Cited By

133

Mammalian PI-Phospholipase C Isozymes: Structural and Functional Insights and Roles in Health and Disease

May Hamdi, Mohammed Al-Matwi · 2025

Medicina

Metrics

133

Citations

154

References

Details

Published: Oct 06, 2015
Vol/Issue: 146(4)
Pages: 508-522
License: View

Authors

P

Pek Siew Lim

Discipline of Biomedical Sciences Faculty of Applied Science University of Canberra Canberra ACT Australia

C

Christopher Ray Sutton

Discipline of Biomedical Sciences Faculty of Applied Science University of Canberra Canberra ACT Australia

S

Sudha Rao

Discipline of Biomedical Sciences Faculty of Applied Science University of Canberra Canberra ACT Australia

Funding

National Health and Medical Research Council Award: APP1025718

Cite This Article

Pek Siew Lim, Christopher Ray Sutton, Sudha Rao (2015). Protein kinase C in the immune system: from signalling to chromatin regulation. Immunology, 146(4), 508-522. https://doi.org/10.1111/imm.12510

Protein kinase C in the immune system: from signalling to chromatin regulation

You May Also Like