Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants

Pamela Viaña‐Mendieta; Mirna Lorena Sánchez; Jorge Benavides

doi:10.1111/iwj.13602

journal article Open Access May 05, 2021

Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants

Pamela Viaña‐Mendieta

Mirna Lorena Sánchez

Jorge Benavides

International Wound Journal Vol. 19 No. 1 pp. 100-113 · Wiley

View at Publisher Save 10.1111/iwj.13602

Abstract

AbstractWound healing is a complex process of communication between growth factors, reactive species of oxygen, cells, signalling pathways, and cytokines in the extracellular matrix, in which growth factors are the key regulators. In humans, the main regulators of the cellular responses in wound healing are five growth factors, namely EGF, bFGF, VEGF, and TGF‐β1. On the other hand, antioxidants such as astaxanthin, beta‐carotene, epigallocatechin gallate, delphinidin, and curcumin have been demonstrated to stimulate cell proliferation, migration and angiogenesis, and control inflammation, to suggest a practical approach to design new strategies to treat non‐healing cutaneous conditions. Based on the individual effects of growth factors and antioxidants, it may be envisioned that the use of both types of bioactives in wound healing formulations may have an additive or synergistic effect on the healing potential. This review addresses the effect of growth factors and antioxidants on wound healing‐related processes. Furthermore, a prospective on their potential additive or synergistic effect on wound healing formulations, based on their individual effects, is presented. This may serve as a guide for the development of a new generation of wound healing formulations.

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Details

Published: May 05, 2021
Vol/Issue: 19(1)
Pages: 100-113
License: View

Authors

P

Pamela Viaña‐Mendieta

Tecnologico de Monterrey Escuela de Ingeniería y Ciencias Monterrey Nuevo León Mexico

M

Mirna Lorena Sánchez

Laboratorio de Materiales Biotecnológicos Departamento de Ciencia y Tecnología Universidad Nacional de Quilmes, IMBICE‐Conicet Bernal Buenos Aires Argentina

J

Jorge Benavides

Tecnologico de Monterrey Escuela de Ingeniería y Ciencias Monterrey Nuevo León Mexico

Funding

Consejo Nacional de Ciencia y Tecnología Award: 1048769

Cite This Article

Pamela Viaña‐Mendieta, Mirna Lorena Sánchez, Jorge Benavides (2021). Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants. International Wound Journal, 19(1), 100-113. https://doi.org/10.1111/iwj.13602

Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants

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