Bronchial reactivity to inhaled histamine: a method and clinical survey

D. W. Cockcroft; D. N. KILLIAN; J. J. A. MELLON; F. E. HARGREAVE

doi:10.1111/j.1365-2222.1977.tb01448.x

journal article May 01, 1977

Bronchial reactivity to inhaled histamine: a method and clinical survey

D. W. Cockcroft D. N. KILLIAN J. J. A. MELLON F. E. HARGREAVE

Clinical & Experimental Allergy Vol. 7 No. 3 pp. 235-243 · Wiley

View at Publisher Save 10.1111/j.1365-2222.1977.tb01448.x

Abstract

SummaryAn easy and safe dose‐response histamine‐inhalation test is described, to measure the level of non‐specific bronchial reactivity.The test was performed in 307 subjects. Non‐specific bronchial reactivity was increased in 3% of presumed normal subjects, in 100% of active asthmatics and in 69% of asymptomatic asthmatics with previous symptoms only at times of exposure to clinically relevant allergens. It was also increased in 47% of patients with cough and no other chest symptoms, in 40% of patients with rhinitis and vague chest symptoms not by themselves diagnostic of asthma, and in 22% of patients with rhinitis and no chest symptoms.The patients with asthma were studied when their asthma was well controlled and when their minimum drug requirements had been established. The mean level of bronchial reactivity increased with increasing minimum drug requirements. The level of bronchial reactivity also showed a strong negative correlation with the forced expiratory volume in 1 sec (FEV1). Atopic subjects, with or without asthma, showed a significant positive correlation between the level of bronchial reactivity and atopic status as indicated by the number of positive allergy skin tests.

Topics

No keywords indexed for this article. Browse by subject →

References

26

[1]

Altounyan R.E.C. (1970)

[2]

Altounyan R.E.C. (1971)

[3]

10.1016/0007-0971(75)90090-x

[4]

Bouhuys A. "Effects of histamine on pulmonary ventilation in man" Clinical Science (1960)

[5]

10.1111/j.1365-2222.1976.tb01919.x

[6]

10.1016/0091-6749(75)90107-4

[7]

Charpin J. (1974)

[8]

10.1172/jci101764

[9]

Dolovich M.B. "Aerosol penetrance: a sensitive index of peripheral airways obstruction" Journal of Applied Physiology (1976) 10.1152/jappl.1976.40.3.468

[10]

Empey D.W. "Mechanism of bronchial hyperreactivity in normal subjects after upper respiratory infection" American Review of Respiratory Disease (1976)

[11]

10.1016/0091-6749(72)90047-4

[12]

10.1159/000227898

[13]

Howell J.B.L. (1971)

[14]

10.1111/j.1365-2222.1976.tb01900.x

[15]

Laitinen L.A. "Histamine and methacholine challenge in the testing of bronchial reactivity" Scandinavian Journal of Respiratory Disease (1974)

[16]

10.1056/nejm197503132921103

[17]

10.1016/0021-8707(66)90036-0

[18]

10.1016/s0140-6736(68)92829-8

[19]

Orehek J. "Les tests de provocation bronchique non‐spécifiques dans l'asthme" Bulletin Europ Physiopathologie Respiratoire (1976)

[20]

Pepys J. "Bronchial provocation tests in etiologic diagnosis and analysis of asthma" American Review of Respiratory Disease (1975)

[21]

10.1016/0091-6749(74)90067-0

[22]

10.1152/jappl.1971.31.1.15

[23]

Tiffeneau R. "Hypersensibilite cholinergo‐histaminique pulmonaire de l'asthmatique" Acta Allergologica (1958)

[24]

10.1016/0021-8707(65)90161-9

[25]

Vries K. (1964)

[26]

Vries K. "Reactivity of the bronchial tree to different stimuli" Bronches (1968)

Cited By

1,384

Asthmatic subjects with allergy have elevated levels of IgE+ B cells in the airways

John-Paul Oliveria, Brittany M. Salter · 2017

Journal of Allergy and Clinical Imm...

Allergen inhalation challenge, refractoriness and the effects of ibuprofen

Shawn Nomani, Donald W. Cockcroft · 2016

Allergy, Asthma & Clinical Immu...

Symptom Perception during Acute Bronchoconstriction

KIERAN J. KILLIAN, RICHARD WATSON · 2000

American Review of Respiratory Dise...

Demonstration of In Vivo Bioequivalence of a Generic Albuterol Metered-Dose Inhaler to Ventolin

Barbara A. Stewart, Richard C. Ahrens · 2000

Chest

Comparison of the Relative Efficacy of Formoterol and Salmeterol in Asthmatic Patients

MONA PALMQVIST, THOMAS IBSEN · 1999

American Review of Respiratory Dise...

Therapeutic Equivalence of Spiros Dry Powder Inhaler and Ventolin Metered Dose Inhaler: A Bioassay Using Methacholine

Richard C. Ahrens, LESLIE HENDELES · 1999

American Review of Respiratory Dise...

Eosinophils in the bronchial mucosa in relation to methacholine dose-response curves in atopic asthma

Gertrude M. Möller, Shelley E. Overbeek · 1999

Journal of Applied Physiology

Changes in airway function and bronchial responsiveness after acute occupational exposure to chlorine leading to treatment in a first aid unit.

C Leroyer, Jean-Luc Malo · 1998

Occupational and Environmental Medi...

Follow-up of Occupational Asthma After Removal From or Diminution of Exposure to the Responsible Agent

Luca Perfetti, André Cartier · 1998

Chest

Comparison of 3 different doses of budesonide and placebo on the early asthmatic response to inhaled allergen

Veronica A. Swystun, Rajesh Bhagat · 1998

Journal of Allergy and Clinical Imm...

Clinical Improvement of Asthma after Anthelminthic Treatment in a Tropical Situation

NEIL R. LYNCH, MIGUEL PALENQUE · 1997

American Review of Respiratory Dise...

Challenge Tests to Assess Airway Hyperresponsiveness and Efficacy of Drugs Used in the Treatment of Asthma

Sandra D. Anderson · 1996

Journal of Aerosol Medicine

Is Delayed Introduction of Inhaled Corticosteroids Harmful in Patients With Obstructive Airways Disease (Asthma and COPD)?

Shelley E. Overbeek, Huib A.M. Kerstjens · 1996

Chest

The Influence of an Inhaled Steroid on Quality of Life in Patients With Asthma or COPD

Constant P. van Schayck, Edward Dompeling · 1995

Chest

Increased Lower Airways Responsiveness Associated with Sinusitis in a Rabbit Model

Susan M. Brugman, Gary L. Larsen · 1993

American Review of Respiratory Dise...

Wheezing and Airflow Obstruction during Methacholine Challenge in Children with Cystic Fibrosis and in Normal Children

Ignacio Sanchez, Richard E. Powell · 1993

American Review of Respiratory Dise...

Assessment of Airway Tone in Asthma: Comparison Between Double Lung Transplant Patients and Healthy Subjects

N. A. Molfino, A. S. Slutsky · 1993

American Review of Respiratory Dise...

Effects of Inhaled Capsaicin in Heart-Lung Transplant Patients and Asthmatic Subjects

Tina J. Hathaway, T. Higenbottam · 1993

American Review of Respiratory Dise...

Response to Isocyanates: Effect of Concentration, Duration of Exposure, and Dose

Olivier Vandenplas, André Cartier · 1993

American Review of Respiratory Dise...

Effects of corticosteroids on bronchodilator action in chronic obstructive lung disease.

J B Wempe, D S Postma · 1992

Thorax

Metrics

1,384

Citations

26

References

Details

Published: May 01, 1977
Vol/Issue: 7(3)
Pages: 235-243
License: View

Authors

Cite This Article

D. W. Cockcroft, D. N. KILLIAN, J. J. A. MELLON, et al. (1977). Bronchial reactivity to inhaled histamine: a method and clinical survey. Clinical & Experimental Allergy, 7(3), 235-243. https://doi.org/10.1111/j.1365-2222.1977.tb01448.x

Bronchial reactivity to inhaled histamine: a method and clinical survey

You May Also Like