Plasma terminal half‐life

P. L. TOUTAIN; A. BOUSQUET‐MÉLOU

doi:10.1111/j.1365-2885.2004.00600.x

journal article Dec 01, 2004

Plasma terminal half‐life

P. L. TOUTAIN A. BOUSQUET‐MÉLOU

Journal of Veterinary Pharmacology and Therapeutics Vol. 27 No. 6 pp. 427-439 · Wiley

View at Publisher Save 10.1111/j.1365-2885.2004.00600.x

Abstract

Terminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limiting factor, the terminal half‐life reflects rate and extent of absorption and not the elimination process (flip‐flop pharmacokinetics). The terminal half‐life is especially relevant to multiple dosing regimens, because it controls the degree of drug accumulation, concentration fluctuations and the time taken to reach equilibrium.

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Citations

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Details

Published: Dec 01, 2004
Vol/Issue: 27(6)
Pages: 427-439
License: View

Authors

Cite This Article

P. L. TOUTAIN, A. BOUSQUET‐MÉLOU (2004). Plasma terminal half‐life. Journal of Veterinary Pharmacology and Therapeutics, 27(6), 427-439. https://doi.org/10.1111/j.1365-2885.2004.00600.x

Plasma terminal half‐life

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