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journal article Mar 07, 2019

The burden of hypertensive disorders of pregnancy in Africa: A systematic review and meta‐analysis

Jean Jacques Noubiap ORCID Jean Joel Bigna ORCID Ulrich Flore Nyaga Ahmadou M. Jingi Arnaud D. Kaze Jobert Richie Nansseu Joël Fokom Domgue ORCID
The Journal of Clinical Hypertension Vol. 21 No. 4 pp. 479-488 · Wiley
View at Publisher Save 10.1111/jch.13514
Abstract
Hypertensive disorders of pregnancy (HDP) are a major contributor to maternal and perinatal morbidity and mortality, especially in resource‐limited settings. Little is known about the magnitude of HDP in Africa. We conducted the first systematic review and meta‐analysis to summarize available data on the prevalence of HDP in Africa. We did a comprehensive literature search to identify review paper published from January 1, 1996, to September 30, 2017, and searched the reference list of retrieved review paper. We used a random‐effects model to estimate the overall and type‐specific prevalence of HDP in Africa. We included 82 studies published between 1997 and 2017 reporting data on a pooled sample of 854 304 women during pregnancy or puerperium. Most studies were hospital‐based, conducted in urban settings across 24 countries. In this population, the overall prevalence of HDP was 100.4‰ (95% CI: 81.4‐121.2). The prevalence was 49.8‰ (95% CI: 32.3‐70.7) for gestational hypertension, 14.7‰ (95% CI: 11.6‐18.2) for chronic hypertension, 9.2‰ (95% CI: 4.2‐16.0) for superimposed preeclampsia, 44.0‰ (95% CI: 36.7‐52.0) for preeclampsia, 22.1‰ (95% CI: 14.8‐30.8) for severe preeclampsia, 14.7‰ (95% CI: 8.1‐23.2) for eclampsia and 2.2‰ (95% CI: 1.2‐3.4) for HELLP syndrome. Prevalence of HDP was significantly higher in Central and Western Africa; there was a consistent tendency of increasing HDP prevalence with income at the country level. In conclusion, the burden of HDP in Africa is high, with about one in 10 pregnancies affected. The higher rate of severe forms of HDP that are associated with significant maternal and perinatal mortality is a major concern in the region.
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References
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Cited By
73
Epidemiology of Maternal Hypertensive Disorders

Yan Zhao, Yue Wang · 2025

Hypertension
Metrics
73
Citations
42
References
Details
Published
Mar 07, 2019
Vol/Issue
21(4)
Pages
479-488
License
View
Authors
J
Jean Jacques Noubiap

Department of Medicine Groote Schuur Hospital, University of Cape Town Cape Town South Africa

J
Jean Joel Bigna

Faculty of Medicine University of Paris Sud XI Le Kremlin‐Bicêtre France

U
Ulrich Flore Nyaga

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

A
Ahmadou M. Jingi

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

A
Arnaud D. Kaze

University of Maryland Medical Center Midtown Campus Baltimore Maryland

J
Jobert Richie Nansseu

Department of Public Health, Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon; Department for the Control of Disease, Epidemics and Pandemics Ministry of Public Health Yaoundé Cameroon

J
Joël Fokom Domgue

Department of Gynecology and Obstetrics Yaoundé University Teaching Hospital Yaoundé Cameroon; Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston Texas

Cite This Article
Jean Jacques Noubiap, Jean Joel Bigna, Ulrich Flore Nyaga, et al. (2019). The burden of hypertensive disorders of pregnancy in Africa: A systematic review and meta‐analysis. The Journal of Clinical Hypertension, 21(4), 479-488. https://doi.org/10.1111/jch.13514
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