A systems biology view of blood vessel growth and remodelling

Elizabeth A. Logsdon; Stacey D. Finley; ALEKSANDER S. POPEL; Feilim Mac Gabhann

doi:10.1111/jcmm.12164

journal article Open Access Nov 17, 2013

A systems biology view of blood vessel growth and remodelling

Elizabeth A. Logsdon Stacey D. Finley ALEKSANDER S. POPEL Feilim Mac Gabhann

Journal of Cellular and Molecular Medicine Vol. 18 No. 8 pp. 1491-1508 · Wiley

View at Publisher Save 10.1111/jcmm.12164

Abstract

AbstractBlood travels throughout the body in an extensive network of vessels – arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels – arterioles, venules and capillaries – can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi‐step morphogenic process of angiogenesis – the sprouting of new blood vessels – and the stability of vascular networksin vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high‐throughput experimentation to the angiogenesis process.

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References

Details

Published: Nov 17, 2013
Vol/Issue: 18(8)
Pages: 1491-1508
License: View

Authors

E

Elizabeth A. Logsdon

Institute for Computational Medicine and Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA

S

Stacey D. Finley

Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD USA

A

ALEKSANDER S. POPEL

Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD USA

F

Feilim Mac Gabhann

Institute for Computational Medicine and Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA

Cite This Article

Elizabeth A. Logsdon, Stacey D. Finley, ALEKSANDER S. POPEL, et al. (2013). A systems biology view of blood vessel growth and remodelling. Journal of Cellular and Molecular Medicine, 18(8), 1491-1508. https://doi.org/10.1111/jcmm.12164

A systems biology view of blood vessel growth and remodelling

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