The multifaceted role of CARD9 in inflammatory bowel disease

Ping Luo; Zhiwen Yang; Bin Chen; Xiaoming Zhong

doi:10.1111/jcmm.14770

journal article Open Access Nov 06, 2019

The multifaceted role of CARD9 in inflammatory bowel disease

Ping Luo

Zhiwen Yang

Bin Chen

Xiaoming Zhong

Journal of Cellular and Molecular Medicine Vol. 24 No. 1 pp. 34-39 · Wiley

View at Publisher Save 10.1111/jcmm.14770

Abstract

AbstractInflammatory bowel disease (IBD) involves a dysregulated immune response to the gut microbiota. Emerging evidence has demonstrated that dysfunctions in caspase recruitment domain‐containing protein 9 (CARD9) may contribute to the pathogenesis of IBD. Interestingly, an allelic series of Card9 variants have both a common predisposing and rare protective function in IBD patients. In this review, we provide mechanistic insights into the role of the CARD9 adaptor molecule in intestinal inflammation and determine a potential CARD9‐targeting therapeutic approach against IBD.

Topics

No keywords indexed for this article. Browse by subject →

References

33

[1]

10.3389/fimmu.2018.00072

[2]

10.1038/s41419-017-0084-6

[3]

10.1053/j.gastro.2013.05.047

[4]

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Bruno Lamas, Mathias L Richard, Valentin Leducq et al.

Nature Medicine 10.1038/nm.4102

[5]

10.1016/j.ajhg.2008.03.016

[6]

10.1089/dna.2012.1605

[7]

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

Floris Imhann, Arnau Vich Vila, Marc Jan Bonder et al.

Gut 10.1136/gutjnl-2016-312135

[8]

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

Manuel A Rivas, Mélissa Beaudoin, Agnes Gardet et al.

Nature Genetics 10.1038/ng.952

[9]

10.1371/journal.pgen.1003723

[10]

10.1136/gutjnl-2014-308617

[11]

10.1016/j.immuni.2015.10.005

[12]

Wang Z "Genetic association between CARD9 variants and inflammatory bowel disease was not replicated in a Chinese Han population" Int J Clin Exp Pathol (2015)

[13]

10.1053/j.gastro.2009.03.007

[14]

10.1016/j.ccr.2009.01.001

[15]

10.1126/science.274.5285.262

[16]

10.1016/j.immuni.2008.11.009

[17]

10.1084/jem.20082683

[18]

10.1053/j.gastro.2017.11.003

[19]

10.1128/jcm.33.8.2064-2068.1995

[20]

10.1084/jem.20072713

[21]

10.1016/j.immuni.2010.12.009

[22]

10.1136/gutjnl-2017-314195

[23]

10.1016/j.chom.2015.04.001

[24]

10.1136/gut.2009.202515

[25]

10.1038/nprot.2016.100

[26]

10.1371/journal.pone.0026988

[27]

10.1152/ajpgi.00509.2010

[28]

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

Teresa Zelante, Rossana G. Iannitti, Cristina Cunha et al.

Immunity 10.1016/j.immuni.2013.08.003

[29]

10.1111/j.1600-065x.2012.01110.x

[30]

10.1016/j.it.2013.02.006

[31]

10.1016/j.coi.2010.10.021

[32]

10.1136/gutjnl-2016-313060

[33]

10.1073/pnas.1705748114

Cited By

43

Innate immune cells in the pathogenesis of inflammatory bowel disease - from microbial metabolites to immune modulation

Rabia S. Mousa, Pietro Invernizzi · 2024

Frontiers in Gastroenterology

The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease

Dickson Kofi Wiredu Ocansey, Sanhua Hang · 2023

Gut Microbes

Metrics

43

Citations

33

References

Details

Published: Nov 06, 2019
Vol/Issue: 24(1)
Pages: 34-39
License: View

Authors

P

Ping Luo

Department of Breast Surgery Nanchang Third Hospital Nanchang China

Z

Zhiwen Yang

Department of Pharmacy Songjiang Hospital Affiliated Shanghai First People’s Hospital Shanghai Jiao Tong University Shanghai China

B

Bin Chen

Surgery Department First Affiliated Hospital of Gannan Medical University Ganzhou China

X

Xiaoming Zhong

Jiangxi Province Tumor Hospital Nanchang China

Cite This Article

Ping Luo, Zhiwen Yang, Bin Chen, et al. (2019). The multifaceted role of CARD9 in inflammatory bowel disease. Journal of Cellular and Molecular Medicine, 24(1), 34-39. https://doi.org/10.1111/jcmm.14770

The multifaceted role of CARD9 in inflammatory bowel disease

You May Also Like