Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Joachim W. Fluhr; David J. Moore; Majella E. Lane; Nadège Lachmann; Anthony V. Rawlings

doi:10.1111/jdv.19745

journal article Open Access Dec 22, 2023

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Joachim W. Fluhr

David J. Moore

Majella E. Lane Nadège Lachmann Anthony V. Rawlings

Journal of the European Academy of Dermatology and Venereology Vol. 38 No. 5 pp. 812-820 · Wiley

View at Publisher Save 10.1111/jdv.19745

Abstract

AbstractThe stratum corneum (SC)—the outermost layer of the epidermis—is the principal permeability and protective barrier of the skin. Different components of the SC, including corneocytes, natural moisturizing factor, a variety of enzymes and their inhibitors, antimicrobial peptides and lipids, work interactively to maintain barrier function. The main barrier properties of the SC are the limitation of water loss and the prevention of infection and contact with potentially harmful exogenous factors. Although the SC functions consistently as a protective barrier throughout the body, variations in functions and morphology occur across body sites with age and skin type. Healthy SC function also depends on the interplay between the chemosensory barrier, the skin's microbiome and the innate immune system. Dysregulation of SC barrier function can lead to the development of skin disorders, such as dry, flaky or sensitive skin, but the complete underlying pathophysiology of these are not fully understood. This review provides insight into the current literature and emerging themes related to epidermal barrier changes that occur in the context of dry, flaky and sensitive skin. Additional studies are needed to further elucidate the underlying aetiology of dry, flaky and sensitive skin and to provide tailored treatment.

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Details

Published: Dec 22, 2023
Vol/Issue: 38(5)
Pages: 812-820
License: View

Authors

J

Joachim W. Fluhr

Institute of Allergology IFA Charité Universitätsmedizin Berlin Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology Berlin Germany

D

David J. Moore

University of Edinburgh Edinburgh UK

M

Majella E. Lane

Department of Pharmaceutics UCL School of Pharmacy London UK

N

Nadège Lachmann

Galderma Sensitive Skincare Faculty Lausanne Switzerland

A

Anthony V. Rawlings

Department of Pharmaceutics UCL School of Pharmacy London UK; AVR Consulting Ltd. Northwich UK

Cite This Article

Joachim W. Fluhr, David J. Moore, Majella E. Lane, et al. (2023). Epidermal barrier function in dry, flaky and sensitive skin: A narrative review. Journal of the European Academy of Dermatology and Venereology, 38(5), 812-820. https://doi.org/10.1111/jdv.19745

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

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