Somatostatin Agonist Pasireotide Promotes a Physiological State Resembling Short‐Day Acclimation in the Photoperiodic Male Siberian Hamster (Phodopus sungorus)

R. A. Dumbell; F. Scherbarth; V. Diedrich; H. A. Schmid; S. Steinlechner; P. Barrett

doi:10.1111/jne.12289

journal article Jun 22, 2015

Somatostatin Agonist Pasireotide Promotes a Physiological State Resembling Short‐Day Acclimation in the Photoperiodic Male Siberian Hamster (Phodopus sungorus)

R. A. Dumbell F. Scherbarth V. Diedrich H. A. Schmid S. Steinlechner

P. Barrett

Journal of Neuroendocrinology Vol. 27 No. 7 pp. 588-599 · Wiley

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Abstract

The timing of growth in seasonal mammals is inextricably linked to food availability. This is exemplified in the Siberian hamster (Phodopus sungorus), which uses the annual cycle of photoperiod to optimally programme energy expenditure in anticipation of seasonal fluctuations in food resources. During the autumn, energy expenditure is progressively minimised by physiological adaptations, including a 30% reduction in body mass, comprising a reduction in both fat and lean tissues. However, the mechanistic basis of this adaptation is still unexplained. We hypothesised that growth hormone (GH) was a likely candidate to underpin these reversible changes in body mass. Administration of pasireotide, a long‐acting somatostatin receptor agonist developed for the treatment of acromegaly, to male hamsters under a long‐day (LD) photoperiod produced a body weight loss. This comprised a reduction in lean and fat mass, including kidneys, testes and brown adipose tissue, typically found in short‐day (SD) housed hamsters. Furthermore, when administered to hamsters switched from SD to LD, pasireotide retarded the body weight increase compared to vehicle‐treated hamsters. Pasireotide did not alter photoperiod‐mediated changes in hypothalamic energy balance gene expression but altered the expression of Srif mRNA expression in the periventricular nucleus and Ghrh mRNA expression in the arcuate nucleus consistent with a reduction in GH feedback and concurrent with reduced serum insulin‐like growth factor‐1. Conversely, GH treatment of SD hamsters increased body mass, which included increased mass of liver and kidneys. Together, these data indicate a role for the GH axis in the determination of seasonal body mass of the Siberian hamster.

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Details

Published: Jun 22, 2015
Vol/Issue: 27(7)
Pages: 588-599
License: View

Authors

R

R. A. Dumbell

Rowett Institute for Nutrition and Health University of Aberdeen Aberdeen UK

F

F. Scherbarth

University of Veterinary Medicine Hannover Hannover Germany

V

V. Diedrich

University of Veterinary Medicine Hannover Hannover Germany

H

H. A. Schmid

Novartis Pharma AG Basel Switzerland

S

S. Steinlechner

University of Veterinary Medicine Hannover Hannover Germany

P

P. Barrett

Rowett Institute for Nutrition and Health University of Aberdeen Aberdeen UK

Funding

German Research Foundation Award: STE 331/8-1

Scottish Government Rural and Environment Science and Analytical Services Division

Cite This Article

R. A. Dumbell, F. Scherbarth, V. Diedrich, et al. (2015). Somatostatin Agonist Pasireotide Promotes a Physiological State Resembling Short‐Day Acclimation in the Photoperiodic Male Siberian Hamster (Phodopus sungorus). Journal of Neuroendocrinology, 27(7), 588-599. https://doi.org/10.1111/jne.12289

Somatostatin Agonist Pasireotide Promotes a Physiological State Resembling Short‐Day Acclimation in the Photoperiodic Male Siberian Hamster (Phodopus sungorus)

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