Review: Chronic endometritis and its effect on reproduction

Fuminori Kimura; Akie Takebayashi; Mitsuaki Ishida; Akiko Nakamura; Jun Kitazawa; Aina Morimune; Kimiko Hirata; Akimasa Takahashi; Shoko Tsuji; Akiko Takashima; Tsukuru Amano; Shunichiro Tsuji; Tetsuo Ono; Shoji Kaku; Kyoko Kasahara; Suzuko Moritani; Ryoji Kushima; Takashi Murakami

doi:10.1111/jog.13937

journal article Mar 06, 2019

Review: Chronic endometritis and its effect on reproduction

Fuminori Kimura

Akie Takebayashi Mitsuaki Ishida Akiko Nakamura

Jun Kitazawa Aina Morimune Kimiko Hirata Akimasa Takahashi

Shoko Tsuji Akiko Takashima Tsukuru Amano Shunichiro Tsuji

Tetsuo Ono Shoji Kaku Kyoko Kasahara Suzuko Moritani Ryoji Kushima Takashi Murakami

Journal of Obstetrics and Gynaecology Research Vol. 45 No. 5 pp. 951-960 · Wiley

View at Publisher Save 10.1111/jog.13937

Abstract

AbstractAimChronic endometritis (CE) is a disease of continuous and subtle inflammation characterized by the infiltration of plasma cells in the endometrial stromal area. Although the clinical significance of CE has been thought in clinical practice for a long time because it is either asymptomatic or presents with subtle symptoms, recent studies have shown the potential adverse effects of CE on fertility. In the present review, we focus on the concept, diagnosis, etiology, pathophysiology, diagnosis, impact on reproduction and treatment for it to understand CE.MethodsThe published articles were reviewed.ResultsThe prevalence of CE has been found to be 2.8–56.8% in infertile women, 14–67.5% in women with recurrent implantation failure (RIF), and 9.3–67.6% in women with recurrent pregnancy loss. Microorganisms are thought to be a main cause of CE, since antibiotic treatment has been reported to be an effective therapy for CE. Common bacteria are frequently detected in the uterine cavity of CE patients by microbial culture. In CE endometrium, the prevalence of immune cells and decidualization has been reported to be modified, and these modifications are thought to adversely affect fertility. The gold standard for the diagnosis of CE is the histological detection of plasma cells in the stromal area of the endometrium in endometrial specimens, although universally accepted criteria for the diagnosis of CE have not been determined. The treatment currently thought to be most effective for the recovery of fertility in CE is administration of oral antibiotics. Patients whose CE has been cured have been reported to have a higher ongoing pregnancy rate, clinical pregnancy rate, and implantation rate compared with patients with persistent CE.ConclusionCE greatly affects implantation and impairs fertility. Antibiotic administration is an effective therapeutic option. Pregnancy rate in in vitro fertilization is improved when CE is cured by antibiotic.

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Metrics

232

Citations

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References

Details

Published: Mar 06, 2019
Vol/Issue: 45(5)
Pages: 951-960
License: View

Authors

F

Fuminori Kimura

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

A

Akie Takebayashi

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

M

Mitsuaki Ishida

Department of Pathology and Laboratory Medicine Kansai Medical University Osaka Japan

A

Akiko Nakamura

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

J

Jun Kitazawa

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

A

Aina Morimune

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

K

Kimiko Hirata

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

A

Akimasa Takahashi

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

S

Shoko Tsuji

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

A

Akiko Takashima

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

T

Tsukuru Amano

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

S

Shunichiro Tsuji

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

T

Tetsuo Ono

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

S

Shoji Kaku

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

K

Kyoko Kasahara

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

S

Suzuko Moritani

Department of Clinical Laboratory Medicine Shiga University of Medical Science Otsu Japan

R

Ryoji Kushima

Department of Clinical Laboratory Medicine Shiga University of Medical Science Otsu Japan

T

Takashi Murakami

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan

Funding

Japan Society for the Promotion of Science Award: 16716425

Cite This Article

Fuminori Kimura, Akie Takebayashi, Mitsuaki Ishida, et al. (2019). Review: Chronic endometritis and its effect on reproduction. Journal of Obstetrics and Gynaecology Research, 45(5), 951-960. https://doi.org/10.1111/jog.13937

Review: Chronic endometritis and its effect on reproduction

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