Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early‐stage tongue squamous cell carcinoma

Nan Xie; Xiqiang Liu; Ruyao Li; Jinsong Hou; Xiaohua Chen; Hongzhang Huang

doi:10.1111/jop.12242

journal article Aug 28, 2014

Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early‐stage tongue squamous cell carcinoma

Nan Xie Xiqiang Liu

Ruyao Li Jinsong Hou Xiaohua Chen

Hongzhang Huang

Journal of Oral Pathology & Medicine Vol. 44 No. 4 pp. 266-272 · Wiley

View at Publisher Save 10.1111/jop.12242

Abstract

BackgroundTumor budding has been suggested to be a prognostic factor in various human cancers. However, the prognostic value of tumor budding for early‐stage (cT1/2N0) tongue squamous cell carcinoma remains inconclusive. This study analyzed the correlation of tumor budding with the clinicopathologic features, and its prognostic significance for cT1/2N0 stage tongue squamous cell carcinoma.MethodsOne hundred and ninety‐five patients with T1/2 stage tongue squamous cell carcinoma enrolled in the retrospective study. Tumor invasive depth, the intensity of tumor budding, and other clinicopathological features were reviewed. Overall survivals were evaluated by the Kaplan–Meier method. For multivariable analysis, Cox's proportional hazards regression models were performed.ResultsThe frequency of tumor buds in tongue squamous cell carcinoma is about 85.6% in this study. The intensity of tumor budding showed strong correlations with occult lymph node metastasis (P < 0.05), local relapse (P < 0.01), worse invasive pattern (P < 0.01), and invasive depth (P < 0.05). The invasive depth was significantly associated with T classification (P < 0.01) and lymph node metastasis (P < 0.01). And both high intensity of tumor budding and deeper invasive depth correlated with reduced overall survival. Cox's regression models proved tumor budding to be an independent prognostic factor in clinical early‐stage tongue squamous cell carcinoma. Tumor local relapses were also a predictor of tongue squamous cell carcinoma progression.ConclusionsTumor budding is a frequent event in tongue squamous cell carcinoma. It independently predicted prognosis of patients with T1/2 stage tongue squamous cell carcinoma and may be used for routing pathological diagnosis and the decision of elective lymph node dissection.

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Metrics

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Citations

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References

Details

Published: Aug 28, 2014
Vol/Issue: 44(4)
Pages: 266-272
License: View

Authors

N

Nan Xie

Department of Oral Pathology Guanghua School of Stomatology Hospital of Stomatology Sun Yat‐sen University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou Guangdong China

X

Xiqiang Liu

Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou Guangdong China; Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Hospital of Stomatology Sun Yat‐sen University Guangzhou Guangdong China

R

Ruyao Li

Department of Oral Pathology Guanghua School of Stomatology Hospital of Stomatology Sun Yat‐sen University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou Guangdong China

J

Jinsong Hou

Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou Guangdong China; Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Hospital of Stomatology Sun Yat‐sen University Guangzhou Guangdong China

X

Xiaohua Chen

Department of Oral Pathology Guanghua School of Stomatology Hospital of Stomatology Sun Yat‐sen University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou Guangdong China

H

Hongzhang Huang

Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou Guangdong China; Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Hospital of Stomatology Sun Yat‐sen University Guangzhou Guangdong China

Funding

Fundamental Research Funds for the Central Universities Award: 11ykpy47

Specialized Research Fund for the Doctoral Program of Higher Education Award: 20120171120068

National Natural Science Grant of China Award: 81272949

Guangdong Province Nature Science Foundation Award: S2013010016848

Cite This Article

Nan Xie, Xiqiang Liu, Ruyao Li, et al. (2014). Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early‐stage tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine, 44(4), 266-272. https://doi.org/10.1111/jop.12242

Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early‐stage tongue squamous cell carcinoma

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