The Association Between Circadian Disruption in Core Body Temperature Rhythm and Post‐Chemotherapy Sleep Disturbances in Breast Cancer Survivors
Sleep disturbance is a common symptom experienced by approximately 70% of breast cancer survivors and persists after the conclusion of chemotherapy. This study aimed to quantify the circadian disruption of the core body temperature (CBT) rhythm and its correlation with sleep disturbance following chemotherapy. In a sample of 25 breast cancer survivors, CBT was measured using an ingestible thermometer pill to calculate the relative amplitude (RA) prior to chemotherapy. The Pittsburgh Sleep Quality Index (PSQI) was employed to assess global sleep quality at three time points: prior to the commencement of chemotherapy, at 1 month (T1) and 9 months (T2) following the conclusion of chemotherapy. Subjective and objective sleep latency (SL
s
and SL
o
) were measured using the PSQI and actigraphy, respectively. The lower RA group exhibited higher intradaily variability of CBT and a higher average temperature of the lowest 5‐h period in comparison to the higher RA group. The lower RA group exhibited lower global sleep quality than the higher RA group at both time points (T1 and T2). SL
s
in the lower RA group were significantly longer compared to the higher RA group at both time points. Furthermore, the discrepancy in SL (∆SL
s
–SL
o
) demonstrated a notable between‐group difference at both time points. The findings of this study suggest that breast cancer survivors with pronounced circadian disruption of the CBT rhythm prior to chemotherapy are more prone to sleep disturbances following chemotherapy. Additionally, prolonged SL
s
may be a contributing factor to their poor sleep quality.
Trial Registration:
clinicaltrials.gov
: NCT04364347
No keywords indexed for this article. Browse by subject →
Freddie Bray, Mathieu Laversanne, Hyuna Sung et al.
Leena Choi, ZHOUWEN LIU, CHARLES E. MATTHEWS et al.
Sharon Schutte-Rodin, Lauren Broch, Daniel Buysse et al.
Showing 50 of 52 references
- Published
- Apr 29, 2025
- Vol/Issue
- 35(2)
- License
- View
You May Also Like
Alexander A. Borbély, Serge Daan · 2016
1,342 citations
Gregory Belenky, Nancy J. Wesensten · 2003
1,067 citations
Lisa Gallicchio, Bindu Kalesan · 2009
805 citations
Dieter Riemann, Colin A. Espie · 2023
613 citations
David A. Kalmbach, Jason R. Anderson · 2018
487 citations