Echocardiographic quantitation of left heart size and function in 122 healthy dogs: A prospective study proposing reference intervals and assessing repeatability

Lance C. Visser; Marisa M. Ciccozzi; Daniel J. Sintov; Ashley N. Sharpe

doi:10.1111/jvim.15562

journal article Open Access Sep 01, 2019

Echocardiographic quantitation of left heart size and function in 122 healthy dogs: A prospective study proposing reference intervals and assessing repeatability

Lance C. Visser Marisa M. Ciccozzi Daniel J. Sintov Ashley N. Sharpe

Journal of Veterinary Internal Medicine Vol. 33 No. 5 pp. 1909-1920 · Oxford University Press (OUP)

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Abstract

Abstract

Background
Broadly applicable reference intervals (RIs) for measurements of left atrial (LA) and left ventricular (LV) size and function generated prospectively using statistically appropriate methods are limited.

Objectives
To generate body size-independent RIs for linear, area, and volume measurements of LA size and LV size and function.

Animals
Healthy adult dogs (n = 122) of variable size and somatotype.

Methods
Prospective study. All dogs underwent an echocardiogram performed by the same examiner. Effects of body weight, sex, age, and heart rate were evaluated by regression and correlation analyses. Scaling exponents and prediction intervals were generated for linear measurements using the allometric equation. After normalization to body weight, 95% RIs were determined using nonparametric methods with 2.5 and 97.5 percentiles serving as the lower and upper limits (each with 90% confidence intervals), respectively.

Results
Linear LA and LV measurements were strongly correlated (R2 ≥ 0.79) with body weight. Scaling exponents were close to the expected 1/3 (0.299-0.392). Prediction intervals for linear measurements of LV chamber size were considerably narrower than previously reported. Weak correlations (r = −0.42 to −0.50) among LV fractional shortening, fractional area change, and ejection fraction and body weight were identified. No other meaningful relationships were identified between the measurements and sex, age, and heart rate.

Conclusions and Clinical Importance
Body size-independent RIs for several linear, area, and volume measurements of LA and LV size and function were generated prospectively from a large and diverse reference population and are available for clinical use.

Topics

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Details

Published: Sep 01, 2019
Vol/Issue: 33(5)
Pages: 1909-1920
License: View

Authors

L

Lance C. Visser

School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California

M

Marisa M. Ciccozzi

School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California

D

Daniel J. Sintov

School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California

A

Ashley N. Sharpe

School of Veterinary Medicine, University of California Department of Medicine & Epidemiology, , Davis, California

Cite This Article

Lance C. Visser, Marisa M. Ciccozzi, Daniel J. Sintov, et al. (2019). Echocardiographic quantitation of left heart size and function in 122 healthy dogs: A prospective study proposing reference intervals and assessing repeatability. Journal of Veterinary Internal Medicine, 33(5), 1909-1920. https://doi.org/10.1111/jvim.15562

Echocardiographic quantitation of left heart size and function in 122 healthy dogs: A prospective study proposing reference intervals and assessing repeatability

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